About this Research Topic

Abstract Submission Deadline 04 September 2022
Manuscript Submission Deadline 03 November 2022

Functional sugars and polyphenols are two key plant-derived nutrients that are essential for human health and disease prevention. However, research that is based on a single intake pattern of plant-derived nutrients may incompletely reflect the interplay of endogenous plant-derived nutrients. Thus, clarifying the interaction mechanism and its accessory nutritional function of plant-derived functional sugars and polyphenols is crucial for the medical and food industry. Recent studies have shown several food-derived functional sugars and polyphenols have potential interaction and further affect the absorption, metabolism, bioavailability, and nutritional function of polyphenols in vitro and in vivo. For example, some functional sugars (stachyose, soluble soybean polysaccharides, jujube date polysaccharides) can significantly enhance the bioavailability of polyphenols (tea flavonoids, genistein, anthocyanins) by down-regulating the expression of intestinal phase II metabolic enzymes and efflux transporters. Additionally, approaches exploiting the strong binding affinity between polysaccharides and phenolic compounds have been used to prepare specific polyphenol-based controlled-release systems. For example, chitosan-based encapsulation nanocarriers (hydrogels, pellets, or spheres) could be applied to the colon-targeted delivery of polyphenols (quercetin, curcumin, resveratrol, rutin). However, the interaction rule and underlining mechanism between food functional sugars and polyphenols still need to be further explored.

The purpose of this research is to provide the latest research information on the interaction mechanism and their combined application in the nutrition regulation of dietary functional sugars and polyphenols. And further dissect the absorption and metabolism rules of polyphenols, thereby achieving the health gain effect by supplementing synergistic dietary functional sugars plus synergistic polyphenols. Additionally, the bioavailability and bioaccessibility of polyphenols could be affected by the crosstalk between dietary functional sugars and polyphenols and the polysaccharides encapsulation of polyphenols, and these functional sugars can improve the bioavailability of polyphenols by regulating metabolic enzymes and efflux transporters in the gastrointestinal tract. However, the reasons for the combination of functional sugars and polyphenols to exert better nutritional effects still need to be further explored. Taken together, in this research, we are dedicated to investigating the nutritional effect and interacting mechanism between dietary functional sugars and polyphenols, which may provide a scientific basis for the area of dietary functional ingredient nutrition and boost the development of functional sugars and polyphenols compound health products.

We welcome manuscripts of different types (Original Research, Perspectives, Mini Reviews, Commentaries, and Opinion papers) from, but not limited to, the following themes:
· Prevention or mitigation of chronic diseases (obesity, colitis, diabetes, liver damage, etc.) through combined or synergistic interventions of food functional sugars and polyphenols;
· Developing targeted delivery systems using polysaccharides as carriers to improve the bioavailability and biological activity of polyphenols;
· Investigating the effects of food functional sugars on physicochemical properties, absorption, metabolism, and bioavailability of polyphenols;
· Studying the interaction mechanism between dietary functional sugars and polyphenols by utilizing the metabolic enzymes and efflux transporters in tissues;
· Exploring the interaction mechanism between food functional sugars and polyphenols based on covalent bonds or non-covalent bonds.

Keywords: oligosaccharides, polysaccharides, polyphenols, interaction, bioavailability, chronic disease prevention


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Functional sugars and polyphenols are two key plant-derived nutrients that are essential for human health and disease prevention. However, research that is based on a single intake pattern of plant-derived nutrients may incompletely reflect the interplay of endogenous plant-derived nutrients. Thus, clarifying the interaction mechanism and its accessory nutritional function of plant-derived functional sugars and polyphenols is crucial for the medical and food industry. Recent studies have shown several food-derived functional sugars and polyphenols have potential interaction and further affect the absorption, metabolism, bioavailability, and nutritional function of polyphenols in vitro and in vivo. For example, some functional sugars (stachyose, soluble soybean polysaccharides, jujube date polysaccharides) can significantly enhance the bioavailability of polyphenols (tea flavonoids, genistein, anthocyanins) by down-regulating the expression of intestinal phase II metabolic enzymes and efflux transporters. Additionally, approaches exploiting the strong binding affinity between polysaccharides and phenolic compounds have been used to prepare specific polyphenol-based controlled-release systems. For example, chitosan-based encapsulation nanocarriers (hydrogels, pellets, or spheres) could be applied to the colon-targeted delivery of polyphenols (quercetin, curcumin, resveratrol, rutin). However, the interaction rule and underlining mechanism between food functional sugars and polyphenols still need to be further explored.

The purpose of this research is to provide the latest research information on the interaction mechanism and their combined application in the nutrition regulation of dietary functional sugars and polyphenols. And further dissect the absorption and metabolism rules of polyphenols, thereby achieving the health gain effect by supplementing synergistic dietary functional sugars plus synergistic polyphenols. Additionally, the bioavailability and bioaccessibility of polyphenols could be affected by the crosstalk between dietary functional sugars and polyphenols and the polysaccharides encapsulation of polyphenols, and these functional sugars can improve the bioavailability of polyphenols by regulating metabolic enzymes and efflux transporters in the gastrointestinal tract. However, the reasons for the combination of functional sugars and polyphenols to exert better nutritional effects still need to be further explored. Taken together, in this research, we are dedicated to investigating the nutritional effect and interacting mechanism between dietary functional sugars and polyphenols, which may provide a scientific basis for the area of dietary functional ingredient nutrition and boost the development of functional sugars and polyphenols compound health products.

We welcome manuscripts of different types (Original Research, Perspectives, Mini Reviews, Commentaries, and Opinion papers) from, but not limited to, the following themes:
· Prevention or mitigation of chronic diseases (obesity, colitis, diabetes, liver damage, etc.) through combined or synergistic interventions of food functional sugars and polyphenols;
· Developing targeted delivery systems using polysaccharides as carriers to improve the bioavailability and biological activity of polyphenols;
· Investigating the effects of food functional sugars on physicochemical properties, absorption, metabolism, and bioavailability of polyphenols;
· Studying the interaction mechanism between dietary functional sugars and polyphenols by utilizing the metabolic enzymes and efflux transporters in tissues;
· Exploring the interaction mechanism between food functional sugars and polyphenols based on covalent bonds or non-covalent bonds.

Keywords: oligosaccharides, polysaccharides, polyphenols, interaction, bioavailability, chronic disease prevention


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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