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About this Research Topic

Manuscript Submission Deadline 31 October 2022
Manuscript Extension Submission Deadline 30 November 2022

Abnormal cellular morphology is one of the defining characteristics of tumor cells. Nowadays, studies focused on modulating the mechanism of cellular morphology and its effect on tumor progression still need to be explored further.

Cellular morphology, which is often transformed to adapt to its external environment, plays a critical role in the regulation of cell activities during tumor progression. The factors determining cellular morphology are complicated, referring to not only the internal regulating factors through mechanotransduction and nuclear shape changes but also the external microenvironment. Growing evidence has revealed that some of the signaling pathways are important for modulation of cellular morphology, and alterations of these pathways have been uncovered in many human malignancies. As such, tremendous effort has been made to understand the mechanisms modulating cellular morphology. However, the regulation of cellular shape remains poorly understood. Previously, the analysis of cellular morphology has been suggested to screen various cancer cell populations and heterogeneity of cellular morphology is one of the hallmarks of tumor progression. Herein, these investigations concerning the cellular structure aim to know the critical role of cellular morphology in tumor progression, which will be beneficial to understand tumor biological process. Furthermore, abnormal cellular morphology might serve as a diagnostic criterion for tumors. In summary, our topic will provide novel insights into tumor prediction and therapy.

This Research Topic welcomes manuscripts related to:

1). Revealing the impact of cellular morphology on tumorigenesis, including the effect on tumorigenesis, tumor metastasis, and so on;

2). Uncovering the modulation of tumor cell morphology, including the internal regulating mechanism such as cellular metabolism, mechanotransduction signaling pathways, and so on;

3). Understanding the effect of tumor microenvironment on tumor cell morphology, involving the external physical forces, chemical stimulation, etc.

Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Keywords: cellular morphology, tumor cell size, cell shape, signaling pathway


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Abnormal cellular morphology is one of the defining characteristics of tumor cells. Nowadays, studies focused on modulating the mechanism of cellular morphology and its effect on tumor progression still need to be explored further.

Cellular morphology, which is often transformed to adapt to its external environment, plays a critical role in the regulation of cell activities during tumor progression. The factors determining cellular morphology are complicated, referring to not only the internal regulating factors through mechanotransduction and nuclear shape changes but also the external microenvironment. Growing evidence has revealed that some of the signaling pathways are important for modulation of cellular morphology, and alterations of these pathways have been uncovered in many human malignancies. As such, tremendous effort has been made to understand the mechanisms modulating cellular morphology. However, the regulation of cellular shape remains poorly understood. Previously, the analysis of cellular morphology has been suggested to screen various cancer cell populations and heterogeneity of cellular morphology is one of the hallmarks of tumor progression. Herein, these investigations concerning the cellular structure aim to know the critical role of cellular morphology in tumor progression, which will be beneficial to understand tumor biological process. Furthermore, abnormal cellular morphology might serve as a diagnostic criterion for tumors. In summary, our topic will provide novel insights into tumor prediction and therapy.

This Research Topic welcomes manuscripts related to:

1). Revealing the impact of cellular morphology on tumorigenesis, including the effect on tumorigenesis, tumor metastasis, and so on;

2). Uncovering the modulation of tumor cell morphology, including the internal regulating mechanism such as cellular metabolism, mechanotransduction signaling pathways, and so on;

3). Understanding the effect of tumor microenvironment on tumor cell morphology, involving the external physical forces, chemical stimulation, etc.

Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Keywords: cellular morphology, tumor cell size, cell shape, signaling pathway


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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