About this Research Topic

Abstract Submission Deadline 30 August 2022
Manuscript Submission Deadline 20 January 2023

Many chronic metabolic diseases, such as obesity, non-alcoholic fatty liver disease (NAFLD), and diabetes, are major global health issues caused by dysfunctions in metabolic organs, such as adipose, liver and pancreas. Thus understanding the precise mechanisms of homeostasis and regeneration of these metabolic organs during normal and pathological conditions, is critical for developing new therapeutic approaches to combat metabolic diseases. Tissue stem cells (TSCs) are multipotent cells that can self-renew and differentiate into the functional progeny, allowing tissues to maintain homeostasis and regenerate after injury. However, the presence of tissue stem cells in the liver and pancreas is still being debated. The heterogeneity of these cell types complicates the process. Furthermore, the trans-differentiation or de-differentiation of mature cell types is also important for tissue homeostasis and regeneration of these metabolic organs. Studies on these topics will undoubtedly broaden and deepen our understanding of the development and progression of metabolic diseases.

Patient-specific pluripotent stem cells can be generated using induced pluripotent stem cells (iPSC) technology, making it a promising platform for drug discovery and cell therapy in metabolic diseases. Isogenic iPSC lines can be created using state-of-the-art gene-editing technologies to investigate the underlying mechanisms of metabolic disease development and progression. Additionally, stem cell-derived organoids that closely resemble naive tissues/organs provide an excellent tool for metabolic disease modeling, drug screening, and cell therapy. Meanwhile, patient-specific iPSCs and organoid biobanking will benefit precision medicine.

This Research Topic focuses on the applications of stem cells and organoids in metabolic disease modeling, drug discovery, and cell therapy, as well as the identification and investigation of tissue stem cell functions in metabolic tissues. We welcome Original Research articles, Review articles, and Perspectives on themes including, but not limited to:
- Identification of tissue stem cells in the liver, pancreas, etc.;
- Cellular heterogeneity of liver, adipose, and pancreas;
- Develop advanced and complexed liver, adipose, and pancreas organoids;
- Metabolic disease modeling using patient-derived iPSCs or organoids;
- Stem cell therapies for metabolic diseases;
- Drug discovery and precision medicine using stem cell and organoid model.

Keywords: stem cell, organoid, metabolism, precision medicine, disease modeling


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Many chronic metabolic diseases, such as obesity, non-alcoholic fatty liver disease (NAFLD), and diabetes, are major global health issues caused by dysfunctions in metabolic organs, such as adipose, liver and pancreas. Thus understanding the precise mechanisms of homeostasis and regeneration of these metabolic organs during normal and pathological conditions, is critical for developing new therapeutic approaches to combat metabolic diseases. Tissue stem cells (TSCs) are multipotent cells that can self-renew and differentiate into the functional progeny, allowing tissues to maintain homeostasis and regenerate after injury. However, the presence of tissue stem cells in the liver and pancreas is still being debated. The heterogeneity of these cell types complicates the process. Furthermore, the trans-differentiation or de-differentiation of mature cell types is also important for tissue homeostasis and regeneration of these metabolic organs. Studies on these topics will undoubtedly broaden and deepen our understanding of the development and progression of metabolic diseases.

Patient-specific pluripotent stem cells can be generated using induced pluripotent stem cells (iPSC) technology, making it a promising platform for drug discovery and cell therapy in metabolic diseases. Isogenic iPSC lines can be created using state-of-the-art gene-editing technologies to investigate the underlying mechanisms of metabolic disease development and progression. Additionally, stem cell-derived organoids that closely resemble naive tissues/organs provide an excellent tool for metabolic disease modeling, drug screening, and cell therapy. Meanwhile, patient-specific iPSCs and organoid biobanking will benefit precision medicine.

This Research Topic focuses on the applications of stem cells and organoids in metabolic disease modeling, drug discovery, and cell therapy, as well as the identification and investigation of tissue stem cell functions in metabolic tissues. We welcome Original Research articles, Review articles, and Perspectives on themes including, but not limited to:
- Identification of tissue stem cells in the liver, pancreas, etc.;
- Cellular heterogeneity of liver, adipose, and pancreas;
- Develop advanced and complexed liver, adipose, and pancreas organoids;
- Metabolic disease modeling using patient-derived iPSCs or organoids;
- Stem cell therapies for metabolic diseases;
- Drug discovery and precision medicine using stem cell and organoid model.

Keywords: stem cell, organoid, metabolism, precision medicine, disease modeling


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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