Research Topic

Preclinical Models of Canine Mammary Neoplasia

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Cancer is increasing, in addition to in humans, also in domestic animals and is especially frequent in dogs and cats. I have worked on mammary tumors in female dogs for about 30 years. These tumors are the most frequent spontaneous tumors in female dogs and they are still poorly understood. All veterinarians ...

Cancer is increasing, in addition to in humans, also in domestic animals and is especially frequent in dogs and cats. I have worked on mammary tumors in female dogs for about 30 years. These tumors are the most frequent spontaneous tumors in female dogs and they are still poorly understood. All veterinarians are familiar with the disease since most unspayed elderly female dogs suffer from mammary tumors. Although about half of the tumors are benign and most of the dogs with diagnosed malignant mammary tumors are cured by surgery, there are several tumors that cause metastases and kill the dog.

My main interest is to delineate the cell of origin in the different phenotypes of mammary tumours that appear. In addition to those with epithelial origin (carcinomas) tumors with a mesenchymal morphology such as fibrosarcomas and osteosarcomas, are common in the dog. Further, complex or mixed tumors i.e. tumors that are composed by more than one neoplastic cell type are frequent in canine neoplastic mammary glands.

Since we are not allowed to do experiments on pet dogs from an ethical point of view there is a need for an experimental set-up in order to investigate the tumors and to test hypotheses. I have therefore established cell lines from tumors obtained from surgically treated dogs.

There has been an increasing interest in the cell lines over the years and in the years 2000 to 2014, 33 scientists signed a Material Transfer Agreement (MTA) to get access to them. Some of these scientists have published several papers using the cell lines whereas others have not published anything (to the best of my knowledge). I think it would be of utmost interest to make a common publication on the results that all the scientists have obtained from their work using these cell lines.

We welcome contributions from scientists who have preclinical models for canine mammary neoplasia that will fit in well in the topic.


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