Most spinal cord injury patients suffer from chronic pain which is referred to as central pain. Traditional treatment for patients suffering from spinal cord injury pain is mainly from pharmacological treatments. However, efficacies of these pharmacological reagents are rarely consistent, and the therapeutic protocols have never been well established. Recently, neuromodulation and rehabilitation has been introduced for the pain therapy and proved to be effective. However, the molecular mechanism of these strategies to reduce the pathological pain has not been well disclosed.This Research Topic wishes to provide a comprehensive understanding of molecular mechanisms responsible for spontaneous and therapeutic plasticity in spinal cord injury induced chronic pain. Neuromodulation and rehabilitation lead to changes both in the spinal cord and brain from transcription to translation of molecules critical for pain related signal pathways. Therefore, this Research Topic aims to analyze the dynamic changes of components in different signal pathways under neuromodulation and rehabilitation therapies, which may uncover a novel target for other therapeutic strategies such as pharmacological treatment.We welcome the submission of papers in any area of pain study related to neuromodulation and rehabilitation. Significant findings that raise important biological and physiological questions related to other diseases related pains are also welcome. Topics to be covered may include but not limit: • Signal pathways• Genetics and epigenetics• Pain receptors• Cell-cell interactions• High-Throughput Sequencing and screening• Neural circuitry
Most spinal cord injury patients suffer from chronic pain which is referred to as central pain. Traditional treatment for patients suffering from spinal cord injury pain is mainly from pharmacological treatments. However, efficacies of these pharmacological reagents are rarely consistent, and the therapeutic protocols have never been well established. Recently, neuromodulation and rehabilitation has been introduced for the pain therapy and proved to be effective. However, the molecular mechanism of these strategies to reduce the pathological pain has not been well disclosed.This Research Topic wishes to provide a comprehensive understanding of molecular mechanisms responsible for spontaneous and therapeutic plasticity in spinal cord injury induced chronic pain. Neuromodulation and rehabilitation lead to changes both in the spinal cord and brain from transcription to translation of molecules critical for pain related signal pathways. Therefore, this Research Topic aims to analyze the dynamic changes of components in different signal pathways under neuromodulation and rehabilitation therapies, which may uncover a novel target for other therapeutic strategies such as pharmacological treatment.We welcome the submission of papers in any area of pain study related to neuromodulation and rehabilitation. Significant findings that raise important biological and physiological questions related to other diseases related pains are also welcome. Topics to be covered may include but not limit: • Signal pathways• Genetics and epigenetics• Pain receptors• Cell-cell interactions• High-Throughput Sequencing and screening• Neural circuitry