Cancer is a complex disease including a large group of almost one hundred types. Breast (in women), prostate (in men), skin, lung and colon cancers are the most common complex cancers people are suffering from around the world. Blood, kidneys, uterus, pancreas, ovaries, bladder, rectum and lymph nodes cancers also kill thousands of people globally every year. For most cases, cancers are observed in, though not limited to, middle-aged to older adults. In the United States alone, more than a half million people die annually due to cancer. Although large numbers of anti-cancer drugs are currently available, potential agents are continuously needed to be discovered to ultimately find a cure for cancer.
In this Research Topic, we aim to collect submissions on organic small molecules, either from synthesis or isolation from natural (plant/marine) sources with their preliminary biological screening data, structure-activity relationships (SARs) analysis, mechanism of action (MoA), and computational analysis for the development of anticancer therapeutics. Biological activities including cytotoxicity, topoisomerase inhibitory activity, enzyme inhibitory activity, etc. will also be covered.
We welcome Original Research, Review, Mini Review and Perspective articles on themes including, but not limited to:
• Design and synthesis of organic small molecules with improved anticancer activity
• Novel tyrosine kinase inhibitors (TKIs) for the treatment of various cancers
• Isolation of novel organic small molecules from plant/marine sources with potent anticancer activity
• Synthesis a series of organic small molecules for the development of anticancer therapeutics
• Derivatives of the biological active molecules with strong or improved anticancer activity
• Computer-aided drug design with wet lab experimental data
Cancer is a complex disease including a large group of almost one hundred types. Breast (in women), prostate (in men), skin, lung and colon cancers are the most common complex cancers people are suffering from around the world. Blood, kidneys, uterus, pancreas, ovaries, bladder, rectum and lymph nodes cancers also kill thousands of people globally every year. For most cases, cancers are observed in, though not limited to, middle-aged to older adults. In the United States alone, more than a half million people die annually due to cancer. Although large numbers of anti-cancer drugs are currently available, potential agents are continuously needed to be discovered to ultimately find a cure for cancer.
In this Research Topic, we aim to collect submissions on organic small molecules, either from synthesis or isolation from natural (plant/marine) sources with their preliminary biological screening data, structure-activity relationships (SARs) analysis, mechanism of action (MoA), and computational analysis for the development of anticancer therapeutics. Biological activities including cytotoxicity, topoisomerase inhibitory activity, enzyme inhibitory activity, etc. will also be covered.
We welcome Original Research, Review, Mini Review and Perspective articles on themes including, but not limited to:
• Design and synthesis of organic small molecules with improved anticancer activity
• Novel tyrosine kinase inhibitors (TKIs) for the treatment of various cancers
• Isolation of novel organic small molecules from plant/marine sources with potent anticancer activity
• Synthesis a series of organic small molecules for the development of anticancer therapeutics
• Derivatives of the biological active molecules with strong or improved anticancer activity
• Computer-aided drug design with wet lab experimental data
