About this Research Topic

Abstract Submission Deadline 11 October 2022
Manuscript Submission Deadline 10 December 2022

Endometriosis is a benign and enigmatic disease estimated to affect 6–10% of women of reproductive age. It has been associated with two significant problems, chronic pelvic pain and subfertility. Endometriosis is an estrogen-dependent disorder described as the presence of endometrial glands and stroma outside the uterine cavity. This disease may have undesirable consequences on a woman's physical and emotional well-being. Accordingly, it may attenuate women's quality of life and productivity. Likewise, Endometriosis can cause substantial economic and social problems for patients, families, and society. Despite its high prevalence, cost, and many published articles, the pathogenesis of Endometriosis remains controversial due to the lack of robust evidence. This issue may consequently restrict our understanding of the disease and decelerate innovation in diagnostic and treatment options.



It is now well accepted that a combination of genetic, hormonal, and immunological factors may contribute to the development of Endometriosis. Endometriosis treatments have been primarily focused on alleviating the symptoms and not the underlying mechanisms of the disease. The nature of individual influencing factors, immune system and peritoneal cavity of women with Endometriosis remains to be elucidated. Although the advances in research over the years have enhanced our understanding associated with hormones and their receptors, immune disorder, the principle of hormonal treatments for Endometriosis, comprehensive and interdisciplinary approaches to disease management, and awareness for patients and health care providers are compulsory to eradicate stigma, intensify an accurate diagnosis and permit for new developments.



The aim of this Research Topic is to cover and provide a platform for researchers to explore and highlight the progress made in endometriosis research including the recent advances in pathological mechanism of endometriosis, detection of new diagnostic and prognostic biomarkers, and novel therapeutic approaches and methodologies for endometriosis management and prevention.



We welcome Original Research, Clinical Trial, and Review papers concerning the following potential topics include but are not limited to the following:

- Novel diagnostic and prognostic biomarkers in hormone-dependent endometriosis

- Recent advances in pathophysiology of endometriosis

- Epigenetics aspect of endometriosis

- Novel pharmacological approaches in endometriosis management

- Recent advances in immunological approaches of endometriosis

- Endometriosis primary and secondary prevention

- Fertility preservation aspect in endometriosis

- Strategies to optimise fertility in endometriosis

- IVF best approach and stimulation techniques in endometriosis

- Clinical approaches in endometriosis management: conservative vs surgery

- Management of endometriosis in peri and post-menopausal state

Keywords: Endometriosis, Diagnosis, IVF, Fertility Preservation


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Endometriosis is a benign and enigmatic disease estimated to affect 6–10% of women of reproductive age. It has been associated with two significant problems, chronic pelvic pain and subfertility. Endometriosis is an estrogen-dependent disorder described as the presence of endometrial glands and stroma outside the uterine cavity. This disease may have undesirable consequences on a woman's physical and emotional well-being. Accordingly, it may attenuate women's quality of life and productivity. Likewise, Endometriosis can cause substantial economic and social problems for patients, families, and society. Despite its high prevalence, cost, and many published articles, the pathogenesis of Endometriosis remains controversial due to the lack of robust evidence. This issue may consequently restrict our understanding of the disease and decelerate innovation in diagnostic and treatment options.



It is now well accepted that a combination of genetic, hormonal, and immunological factors may contribute to the development of Endometriosis. Endometriosis treatments have been primarily focused on alleviating the symptoms and not the underlying mechanisms of the disease. The nature of individual influencing factors, immune system and peritoneal cavity of women with Endometriosis remains to be elucidated. Although the advances in research over the years have enhanced our understanding associated with hormones and their receptors, immune disorder, the principle of hormonal treatments for Endometriosis, comprehensive and interdisciplinary approaches to disease management, and awareness for patients and health care providers are compulsory to eradicate stigma, intensify an accurate diagnosis and permit for new developments.



The aim of this Research Topic is to cover and provide a platform for researchers to explore and highlight the progress made in endometriosis research including the recent advances in pathological mechanism of endometriosis, detection of new diagnostic and prognostic biomarkers, and novel therapeutic approaches and methodologies for endometriosis management and prevention.



We welcome Original Research, Clinical Trial, and Review papers concerning the following potential topics include but are not limited to the following:

- Novel diagnostic and prognostic biomarkers in hormone-dependent endometriosis

- Recent advances in pathophysiology of endometriosis

- Epigenetics aspect of endometriosis

- Novel pharmacological approaches in endometriosis management

- Recent advances in immunological approaches of endometriosis

- Endometriosis primary and secondary prevention

- Fertility preservation aspect in endometriosis

- Strategies to optimise fertility in endometriosis

- IVF best approach and stimulation techniques in endometriosis

- Clinical approaches in endometriosis management: conservative vs surgery

- Management of endometriosis in peri and post-menopausal state

Keywords: Endometriosis, Diagnosis, IVF, Fertility Preservation


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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