About this Research Topic

Manuscript Submission Deadline 24 November 2022

Central serotonin (5-HT), as a neurotransmitter, plays a critical role in the regulation of mood, sleep, feeding behavior, and energy homeostasis. Among the 5-HT receptor subtype, 5-HT2C receptor has been implicated as the major target of regulating feeding behavior, and the selective 5-HT2CR agonist, lorcaserin, has been used as the anti-obesity agent. Peripheral 5-HT, as an endocrine hormone, has been also suggested as the critical regulator of energy metabolism. Recent basic studies have suggested that peripheral 5-HT contributes to the pathophysiological mechanisms of metabolic diseases including obesity, diabetes and NAFLD, and peripheral 5-HT synthesis and 5-HT signaling on metabolic organs including gut, liver, adipose tissue, and pancreas have been suggested as the novel therapeutic target of the metabolic diseases.


The aim of this Research Topic is to give insight into the evolving field of the serotonin and metabolic diseases, which includes obesity, diabetes and NAFLD. In the basic research, this research topic explores molecular regulatory system of 5-HT synthesis and metabolism in the central nervous system and/or peripheral organs, nutritional and/or pharmacologic effects on the 5-HT synthesis and signals, the role of 5-HT in the regulation of insulin, leptin and FGF21 secretion, glucose homeostasis and adiposity. In clinical research, this research topic explores role of 5-HT in the development and /or prevention of metabolic diseases, and finds novel nutritional and/or pharmacologic molecules, which may be available for the treatment of metabolic diseases in future.


This Research Topic aims to assemble original research articles, brief reports, opinion papers, reviews, or commentaries that provide new information, or molecular and/or physiological insight into how 5-HT is synthesized, secreted, and acted on metabolic tissues, leading to alterations of body weight, glucose and lipid metabolism, and how 5-HT signaling systems are integrated at the level of the gut and brain. Topics that will be covered, but are not limited to, include:

-Nutrient-sensing in 5-HT synthesis and secretion

-Role of central and peripheral 5-HT systems in glucose homeostasis

-Novel 5-HT activity mechanisms in health and metabolic diseases including obesity, diabetes and NAFLD

-Pharmacogenomics

-Crosstalk in 5-HT and other hormones

-Novel tools to study 5-HT signaling in these physiological systems

Keywords: Serotonin, obesity, diabetes, NAFLD/NASH, metabolism


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Central serotonin (5-HT), as a neurotransmitter, plays a critical role in the regulation of mood, sleep, feeding behavior, and energy homeostasis. Among the 5-HT receptor subtype, 5-HT2C receptor has been implicated as the major target of regulating feeding behavior, and the selective 5-HT2CR agonist, lorcaserin, has been used as the anti-obesity agent. Peripheral 5-HT, as an endocrine hormone, has been also suggested as the critical regulator of energy metabolism. Recent basic studies have suggested that peripheral 5-HT contributes to the pathophysiological mechanisms of metabolic diseases including obesity, diabetes and NAFLD, and peripheral 5-HT synthesis and 5-HT signaling on metabolic organs including gut, liver, adipose tissue, and pancreas have been suggested as the novel therapeutic target of the metabolic diseases.


The aim of this Research Topic is to give insight into the evolving field of the serotonin and metabolic diseases, which includes obesity, diabetes and NAFLD. In the basic research, this research topic explores molecular regulatory system of 5-HT synthesis and metabolism in the central nervous system and/or peripheral organs, nutritional and/or pharmacologic effects on the 5-HT synthesis and signals, the role of 5-HT in the regulation of insulin, leptin and FGF21 secretion, glucose homeostasis and adiposity. In clinical research, this research topic explores role of 5-HT in the development and /or prevention of metabolic diseases, and finds novel nutritional and/or pharmacologic molecules, which may be available for the treatment of metabolic diseases in future.


This Research Topic aims to assemble original research articles, brief reports, opinion papers, reviews, or commentaries that provide new information, or molecular and/or physiological insight into how 5-HT is synthesized, secreted, and acted on metabolic tissues, leading to alterations of body weight, glucose and lipid metabolism, and how 5-HT signaling systems are integrated at the level of the gut and brain. Topics that will be covered, but are not limited to, include:

-Nutrient-sensing in 5-HT synthesis and secretion

-Role of central and peripheral 5-HT systems in glucose homeostasis

-Novel 5-HT activity mechanisms in health and metabolic diseases including obesity, diabetes and NAFLD

-Pharmacogenomics

-Crosstalk in 5-HT and other hormones

-Novel tools to study 5-HT signaling in these physiological systems

Keywords: Serotonin, obesity, diabetes, NAFLD/NASH, metabolism


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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