About this Research Topic
Alzheimer’s disease is becoming increasingly recognized for its systemic nature. Increased Alzheimer’s Disease risk has been associated with diabetes, cardiovascular disease, and cardiorespiratory fitness. Recent work has described strong associations between liver health and the incidence of probable Alzheimer’s Disease. Additionally, growing evidence indicates that numerous metabolic changes have been observed beyond the brain in subjects with Alzheimer’s disease, including within blood, skin, and muscle.
Despite these intriguing discoveries, the importance and relevance of these findings are yet to be determined. Further exploration is required to understand if systemic changes develop as a result of Alzheimer’s disease or if they contribute to the progression of the disease. A broader comprehension of the etiology of the neurodegenerative disease and the interaction with systemic manifestations could ultimately lead to modifications in treatments.
In this Research Topic, we will aim to address key aspects of systemic alterations and their role in Alzheimer’s Disease risk to recognize and understand the systemic nature of the disease. We hope to promote necessary and integral discussion around this theme to facilitate knowledge dissemination.
We encourage examples of high-priority Original Research, Review, Methods, and Perspective articles topics on the following sub-topics, although manuscripts investigating the role of other peripheral systems in Alzheimer’s Disease pathophysiology are also welcome:
- The role liver health plays in brain health across aging and cognition/AD hallmarks
- Biomarkers of systemic health in AD and probable AD
- Implications of diabetes in increased AD risk
- How cardiorespiratory fitness alters AD risk
- The role genetic factors, such as APOE, play in modulating systemic factors and AD risk
Despite these intriguing discoveries, the importance and relevance of these findings are yet to be determined. Further exploration is required to understand if systemic changes develop as a result of Alzheimer’s disease or if they contribute to the progression of the disease. A broader comprehension of the etiology of the neurodegenerative disease and the interaction with systemic manifestations could ultimately lead to modifications in treatments.
In this Research Topic, we will aim to address key aspects of systemic alterations and their role in Alzheimer’s Disease risk to recognize and understand the systemic nature of the disease. We hope to promote necessary and integral discussion around this theme to facilitate knowledge dissemination.
We encourage examples of high-priority Original Research, Review, Methods, and Perspective articles topics on the following sub-topics, although manuscripts investigating the role of other peripheral systems in Alzheimer’s Disease pathophysiology are also welcome:
- The role liver health plays in brain health across aging and cognition/AD hallmarks
- Biomarkers of systemic health in AD and probable AD
- Implications of diabetes in increased AD risk
- How cardiorespiratory fitness alters AD risk
- The role genetic factors, such as APOE, play in modulating systemic factors and AD risk
Keywords: Alzheimer’s Disease, Systemic Implications, Metabolic Changes
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
