About this Research Topic
The human body harbours complex microbial communities that are not evenly distributed throughout the body and vary in taxa composition and abundance depending on the body’s habitat. Our microbial habitats are not isolated from one another. Instead, each individual harbours a complex but intertwined microbial landscape that encompasses various body habitats. For instance, the gastrointestinal tract extends from the mouth to the anus and harbours diverse bacterial communities. Previous studies have described the composition and dynamics of human bacterial communities in the oral cavity and intestine and their crucial roles in health and disease. In addition, the presence of certain oral species of Streptococcus, Campylobacter, and Fusobacterium among the gut microbiota has been significantly associated with disease states such as inflammatory bowel disease. However, the fundamental role of oral bacteria colonizing the human gut remains to be elucidated.
Although our understanding of bacterial evolution and adaptation in a defined human habitat has progressed, the mechanisms underlying the adaptation of oral bacterial species to the gut remain elusive. Therefore, the goal of this research topic is to explore new insights into the oral-gut axis and the role of the oral microbiota in gastrointestinal diseases, as well as the mechanisms underlying the molecular evolution and adaptation of oral bacteria to the gut. Finally, we believe that this research topic will be able to provide fundamental guidance to researchers in this field.
We welcome the submission of all types of manuscripts, including original research, review, mini-review, perspective, brief research report, and general commentary focusing on, but not limited to, the following topics:
• Oral-gut axis
• Oral-gut microbiota
• Oral microbiome dysbiosis and gastrointestinal diseases
• Oral diseases and gut microbiome dysbiosis
• Ectopic gut colonization
• Within‐Host Evolution of commensal and pathogenic oral bacteria
Although our understanding of bacterial evolution and adaptation in a defined human habitat has progressed, the mechanisms underlying the adaptation of oral bacterial species to the gut remain elusive. Therefore, the goal of this research topic is to explore new insights into the oral-gut axis and the role of the oral microbiota in gastrointestinal diseases, as well as the mechanisms underlying the molecular evolution and adaptation of oral bacteria to the gut. Finally, we believe that this research topic will be able to provide fundamental guidance to researchers in this field.
We welcome the submission of all types of manuscripts, including original research, review, mini-review, perspective, brief research report, and general commentary focusing on, but not limited to, the following topics:
• Oral-gut axis
• Oral-gut microbiota
• Oral microbiome dysbiosis and gastrointestinal diseases
• Oral diseases and gut microbiome dysbiosis
• Ectopic gut colonization
• Within‐Host Evolution of commensal and pathogenic oral bacteria
Keywords: Oral microbiome, gut microbiome, oral-gut axis, ectopic colonization, within-host adaptation
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
