About this Research Topic
In general, the gut microbiota maintains a state of balance with the human body and the external environment, and it plays an important role in human health. However, in some cases, this balance can be disrupted, resulting in dysbiosis of the gut microbiota, which can lead to or exacerbate disease, complications and even multiple organ dysfunction syndromes and multiple organ failure. Disruptions in the gut microbiota are specifically linked to the occurrence of immune imbalance diseases such as autoimmune diseases, tumors, and metabolic syndrome.
Evidence indicated that many natural products are metabolized by gut microbiota in the gastrointestinal tract after oral administration, and their metabolites are absorbed into the blood to exert pharmacological effects. Some gut microbiota can boost metabolite absorption, improve bioavailability, and reduce or enhance toxicity. Environmentally induced changes in the gut microbiota can also affect the metabolism of some natural products, affecting their pharmacokinetics and biological effects. Understanding the metabolic process and mechanism of natural products under the regulation of gut microbiota is, therefore critical for guiding clinical medication and promoting drug development.
This Research Topic aims to collate cutting-edge Reviews, Commentaries, and Original Research articles on the mechanisms by which natural products modulate the gut microbiome, including but not limited to autoimmunity diseases, cancer and metabolic diseases.
The following subtopics are welcome but not limited to:
1. Molecular mechanisms of natural products affecting changes in gut microbiota;
2. Influence of natural product secondary metabolites on gut microbiota;
3. Secondary development of natural products that affect the balance of gut microbiota;
4. Study on the mechanism of fecal microbiota transplantation on disease;
5. The regulatory mechanism of medicinal and food homologous natural products on gut microbiota.
Evidence indicated that many natural products are metabolized by gut microbiota in the gastrointestinal tract after oral administration, and their metabolites are absorbed into the blood to exert pharmacological effects. Some gut microbiota can boost metabolite absorption, improve bioavailability, and reduce or enhance toxicity. Environmentally induced changes in the gut microbiota can also affect the metabolism of some natural products, affecting their pharmacokinetics and biological effects. Understanding the metabolic process and mechanism of natural products under the regulation of gut microbiota is, therefore critical for guiding clinical medication and promoting drug development.
This Research Topic aims to collate cutting-edge Reviews, Commentaries, and Original Research articles on the mechanisms by which natural products modulate the gut microbiome, including but not limited to autoimmunity diseases, cancer and metabolic diseases.
The following subtopics are welcome but not limited to:
1. Molecular mechanisms of natural products affecting changes in gut microbiota;
2. Influence of natural product secondary metabolites on gut microbiota;
3. Secondary development of natural products that affect the balance of gut microbiota;
4. Study on the mechanism of fecal microbiota transplantation on disease;
5. The regulatory mechanism of medicinal and food homologous natural products on gut microbiota.
Keywords: natural product, gut microbiota, autoimmune diseases, tumors, metabolic syndrome
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
