About this Research Topic
Autoimmune optic neuritis and hereditary optic neuropathies, including Leber hereditary optic neuropathy (LHON) and autosomal dominant optic atrophy (ADOA), are both challenging in diagnosis and treatment in clinical practice. In the last decade, the detection and identification of novel body liquid biomarkers, including aquaporin 4-IgG antibody (AQP4-Ab) and myelin oligodendrocyte glycoprotein-IgG antibody (MOG-Ab), as well as novel mutations in nuclear genes such as OPA1, PRICKLE3, and DNAJC30, have markedly promoted our understanding about etiology, pathogenesis, and prognosis of autoimmune optic neuritis and hereditary optic neuropathies. Unfortunately, the positive results of the above biomarkers in autoimmune optic neuritis cases and hereditary optic neuropathy suspects are still not high enough. Therefore, more investigations about current and other potential novel humoral, genetic, and imaging biomarkers need to be done to further evaluate the diagnosis, prognosis, and prediction of autoimmune and hereditary optic neuropathies.
This Research Topic aims to collect the most recent progressions in basic and clinical investigations about humoral, genetic, and imaging biomarkers for autoimmune and hereditary optic neuropathies, especially the detection and identification of novel biomarkers showing probability in clinical translation. We would like to present the latest advances in the diagnosis, prognosis, and prediction of autoimmune and hereditary optic neuropathies, including but not limited to, demyelinating optic neuritis, paraneoplastic optic neuropathy, LHON, ADOA, Wolfram syndrome, and other rare autosomal recessive optic atrophies.
This Research Topic welcomes submissions of the following article types: Original Research, Brief Research Reports, Clinical Trial Studies, and Review, including but not limited to:
- Detection and identification of novel biomarkers for autoimmune optic neuritis and hereditary optic neuropathy
- Body fluid biomarkers for autoimmune optic neuritis and hereditary optic neuropathy
- Genetic biomarkers for autoimmune optic neuritis and hereditary optic neuropathy
- Radiological or ophthalmic imaging biomarkers for autoimmune optic neuritis and hereditary optic neuropathy
- Molecular mechanism of biomarkers in the development and evolution of autoimmune optic neuritis and hereditary optic neuropathy
This Research Topic aims to collect the most recent progressions in basic and clinical investigations about humoral, genetic, and imaging biomarkers for autoimmune and hereditary optic neuropathies, especially the detection and identification of novel biomarkers showing probability in clinical translation. We would like to present the latest advances in the diagnosis, prognosis, and prediction of autoimmune and hereditary optic neuropathies, including but not limited to, demyelinating optic neuritis, paraneoplastic optic neuropathy, LHON, ADOA, Wolfram syndrome, and other rare autosomal recessive optic atrophies.
This Research Topic welcomes submissions of the following article types: Original Research, Brief Research Reports, Clinical Trial Studies, and Review, including but not limited to:
- Detection and identification of novel biomarkers for autoimmune optic neuritis and hereditary optic neuropathy
- Body fluid biomarkers for autoimmune optic neuritis and hereditary optic neuropathy
- Genetic biomarkers for autoimmune optic neuritis and hereditary optic neuropathy
- Radiological or ophthalmic imaging biomarkers for autoimmune optic neuritis and hereditary optic neuropathy
- Molecular mechanism of biomarkers in the development and evolution of autoimmune optic neuritis and hereditary optic neuropathy
Keywords: Biomarker, Demyelinating Optic Neuritis, Paraneoplastic Optic Neuropathy, Hereditary Optic Neuropathy
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
