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About this Research Topic

Abstract Submission Deadline 01 March 2023
Manuscript Submission Deadline 01 May 2023

Gastrointestinal cancers, the most common cancers around the world, have seriously threatened human health. They can be induced by a variety of factors including gene mutations in epithelial cells and changes in the immune microenvironment. The synergy between these factors leads to the occurrence and development of gastrointestinal cancers. Although progress has been made in understanding the pathogenesis of gastrointestinal cancers, the detailed mechanisms are far from being clarified.

This Research Topic aims to reveal the molecular and immune mechanisms of various gastrointestinal cancers including colon cancer, liver cancer, and pancreatic cancer. We are especially interested in the changes and mechanisms of the tissue epithelial cells that induce and promote the diseases (including gene mutations, stemness changes, signaling pathway changes, metabolic changes), as well as the changes of the immune microenvironment at the initiation stage of disease induction. Studies using animal models and/or clinical specimens are particularly welcomed. We hope that by exploring the pathogenesis of gastrointestinal cancers at a systematic level we could shed some light on the prevention of these diseases.

We welcome submissions related to but not limited to the following sub-topics:
• The epithelial cell changes that can induce gastrointestinal cancers and the molecular mechanisms, including gene mutations, stemness changes, signaling pathway changes, and metabolic changes;
• The immune microenvironment changes that can induce gastrointestinal cancers and the involved mechanisms, including changes of immune cell subsets in the microenvironment, including changes in the number and function of immune cells, and changes of immune cytokines in microenvironment;
• Synergism between epithelial cell changes and immune microenvironment changes which induces and promotes gastrointestinal tumors, including regulation of epithelial cell changes on immune microenvironment and effect of immune microenvironment on tissue epithelial cells.

Keywords: gastrointestinal cancers, molecular mechanisms, immune mechanisms, epithelial cells, immune microenvironment


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Gastrointestinal cancers, the most common cancers around the world, have seriously threatened human health. They can be induced by a variety of factors including gene mutations in epithelial cells and changes in the immune microenvironment. The synergy between these factors leads to the occurrence and development of gastrointestinal cancers. Although progress has been made in understanding the pathogenesis of gastrointestinal cancers, the detailed mechanisms are far from being clarified.

This Research Topic aims to reveal the molecular and immune mechanisms of various gastrointestinal cancers including colon cancer, liver cancer, and pancreatic cancer. We are especially interested in the changes and mechanisms of the tissue epithelial cells that induce and promote the diseases (including gene mutations, stemness changes, signaling pathway changes, metabolic changes), as well as the changes of the immune microenvironment at the initiation stage of disease induction. Studies using animal models and/or clinical specimens are particularly welcomed. We hope that by exploring the pathogenesis of gastrointestinal cancers at a systematic level we could shed some light on the prevention of these diseases.

We welcome submissions related to but not limited to the following sub-topics:
• The epithelial cell changes that can induce gastrointestinal cancers and the molecular mechanisms, including gene mutations, stemness changes, signaling pathway changes, and metabolic changes;
• The immune microenvironment changes that can induce gastrointestinal cancers and the involved mechanisms, including changes of immune cell subsets in the microenvironment, including changes in the number and function of immune cells, and changes of immune cytokines in microenvironment;
• Synergism between epithelial cell changes and immune microenvironment changes which induces and promotes gastrointestinal tumors, including regulation of epithelial cell changes on immune microenvironment and effect of immune microenvironment on tissue epithelial cells.

Keywords: gastrointestinal cancers, molecular mechanisms, immune mechanisms, epithelial cells, immune microenvironment


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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