About this Research Topic
The risk of reproductive problems, such as infertility, miscarriage, and ongoing pregnancy complications, increases as women age. While chromosomal errors play a significant role, environmental exposures are increasingly appreciated to play a role in modifying gene expression through epigenetic regulation during development, and may also affect fetal growth and later fertility. Taking advantage of the open access and interactive platform in the Frontiers in Genetics, we would like to bring together high impact research studies and novel insights on this topic in order to facilitate and stimulate discussion, and improve our understanding on the cause of reproductive disorders. The issue will focus on application of genetic and genomic technologies to understand the biology of reproduction as it relates to human reproductive problems (including but not limited to infertility, pregnancy loss, intrauterine growth restriction, preeclampsia, and congenital abnormalities). We have a broad interest in chromosome and gene studies as they relate to reproduction and specifically welcome submissions demonstrating application of next generation sequencing, array CGH, epigenetic investigations and prenatal genetic diagnosis to elucidate the mechanisms and causes of human reproductive problems. We welcome submissions of article types including Original Research, Methods, Hypothesis & Theory, Clinical study, Reviews and Perspectives.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.