About this Research Topic
Platelets are small anucleate blood cells that are typically associated with the process of haemostasis. However, it is now apparent that platelets are more complex than originally thought, with their function extending beyond their traditional role in haemostasis and thrombosis. Platelets play an active role in several pathophysiological processes, from inflammatory response to cancer dissemination and neurological diseases. In addition, emerging data show that platelets can release multiple factors from granules, biomediators, and membrane vesicles, influencing pathophysiological processes.
Despite the knowledge about the function of platelets in haemostasis, much remains to be studied and discovered about how they are able to influence different diseases. In this Research Topic we aim to bring together the latest research on the multi-faceted roles of platelets in health and disease, as well as in the diagnosis and therapeutics of diseases. This ranges from studies of platelet physiology to their complex interactions with other cells in pathophysiological settings, focusing on molecular pathways. In addition to this we also welcome research on new imaging techniques and in vivo and in vitro models that may boost new discoveries in the field of platelets.
The aim of this Research Topic is to cover promising and novel research trends in the platelet field, as well as deciphering their role in causing disease and potential therapies for this. Review, Original Research & Mini-Review articles to be included in this Research Topic are expected to be related to themes including, but not limited to molecular mechanisms and/or insights into the following:
• Platelets and Atherothrombosis
• Platelets and Cardiovascular system and Cardiovascular diseases
• Platelets and cancer diagnostics and therapeutics
• Platelet imaging
• Molecular Mechanisms of Platelet formation
• Mouse models to probe platelet biology
• Platelet-immune cell interaction and potential therapeutic opportunities
• Platelet Biogenesis and Physiology
• Platelets and neurodegenerative diseases
• New antiplatelet therapy
• Platelet-derived extracellular vesicles
• Technology for functional platelet production ex vivo
Despite the knowledge about the function of platelets in haemostasis, much remains to be studied and discovered about how they are able to influence different diseases. In this Research Topic we aim to bring together the latest research on the multi-faceted roles of platelets in health and disease, as well as in the diagnosis and therapeutics of diseases. This ranges from studies of platelet physiology to their complex interactions with other cells in pathophysiological settings, focusing on molecular pathways. In addition to this we also welcome research on new imaging techniques and in vivo and in vitro models that may boost new discoveries in the field of platelets.
The aim of this Research Topic is to cover promising and novel research trends in the platelet field, as well as deciphering their role in causing disease and potential therapies for this. Review, Original Research & Mini-Review articles to be included in this Research Topic are expected to be related to themes including, but not limited to molecular mechanisms and/or insights into the following:
• Platelets and Atherothrombosis
• Platelets and Cardiovascular system and Cardiovascular diseases
• Platelets and cancer diagnostics and therapeutics
• Platelet imaging
• Molecular Mechanisms of Platelet formation
• Mouse models to probe platelet biology
• Platelet-immune cell interaction and potential therapeutic opportunities
• Platelet Biogenesis and Physiology
• Platelets and neurodegenerative diseases
• New antiplatelet therapy
• Platelet-derived extracellular vesicles
• Technology for functional platelet production ex vivo
Keywords: Platelets, Platelet Formation, Mouse Models, Cancer, Blood Cells, Pathophysiological, Membrane Vesicles, Biomediators, Neurological Disease, Extracellular Vesicles, Antiplatelet therapy
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
