About this Research Topic

Abstract Submission Deadline 01 November 2022
Manuscript Submission Deadline 30 November 2022

Nowadays, society is constantly exposed to stress. Sometimes it is mobilizing stress, which is the body's natural reaction to changes, challenges, and threats, but more often - especially when it persists for a long time, stress can be detrimental to health. Chronic stress weakens the functioning of many systems in our body, including the nervous system. A healthy body can cope with a certain level of stress and restore mental balance once it has subsided. However, too much stress can lead to mental overload and the development of mental illness.

Currently, depression is one of the most common mental illnesses in medical practice. However, bipolar disorder, dementia, and schizophrenia are also very serious health problems. The symptoms of mental disorders have been known to man since the dawn of time. Currently, however, highly effective therapies are still not known, therefore the great economic and social burden associated with mental disorder is growing every year. Abnormalities in serotonergic signaling have been believed to be a risk factor in the pathogenesis of the psychiatric disorder. However, despite decades of research, many of their molecular mechanisms related to serotonin receptors remain a mystery to us.

This Research Topic will focus on the role of serotonin receptors in synaptic plasticity, molecular downstream signaling of individual receptors, and their influence on animal behavior. We welcome the submission of all types of articles i.e., Original Research, Review, Methods, and Perspective article.

Keywords: serotonin, depression, bipolar disorder, dementia, schizophrenia, serotonergic signaling, serotonin receptors, synaptic plasticity, animal behavior


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Nowadays, society is constantly exposed to stress. Sometimes it is mobilizing stress, which is the body's natural reaction to changes, challenges, and threats, but more often - especially when it persists for a long time, stress can be detrimental to health. Chronic stress weakens the functioning of many systems in our body, including the nervous system. A healthy body can cope with a certain level of stress and restore mental balance once it has subsided. However, too much stress can lead to mental overload and the development of mental illness.

Currently, depression is one of the most common mental illnesses in medical practice. However, bipolar disorder, dementia, and schizophrenia are also very serious health problems. The symptoms of mental disorders have been known to man since the dawn of time. Currently, however, highly effective therapies are still not known, therefore the great economic and social burden associated with mental disorder is growing every year. Abnormalities in serotonergic signaling have been believed to be a risk factor in the pathogenesis of the psychiatric disorder. However, despite decades of research, many of their molecular mechanisms related to serotonin receptors remain a mystery to us.

This Research Topic will focus on the role of serotonin receptors in synaptic plasticity, molecular downstream signaling of individual receptors, and their influence on animal behavior. We welcome the submission of all types of articles i.e., Original Research, Review, Methods, and Perspective article.

Keywords: serotonin, depression, bipolar disorder, dementia, schizophrenia, serotonergic signaling, serotonin receptors, synaptic plasticity, animal behavior


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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