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The human brain is constantly exposed to exogenous and endogenous sensory information. This requires a high level of information filtering and higher-order cognitive processing before sensory information can be perceived, understood, and consciously processed, in order to recognize, evaluate this information ...

The human brain is constantly exposed to exogenous and endogenous sensory information. This requires a high level of information filtering and higher-order cognitive processing before sensory information can be perceived, understood, and consciously processed, in order to recognize, evaluate this information and select an adequate response. Over the last few decades, it has become possible to get a glimpse of the complexity of these processes by utilizing several noninvasive neuroimaging methods, such as EEG, MRI, NIRS, and PET.

Due to a countless number of neuroimaging studies, our understanding of how the human brain works have been substantially deepened and expanded. The reliability and reproducibility of the results, however, have been recently questioned and exposed in the spotlight. Specifically, the replication crisis demines or degenerates the sincerity and integrity of the research field and needs to be addressed and clarified.

Accordingly, the goals of this Research Topic are primarily threefold.
1. To address how exogenous and endogenous factors affect the brain imaging results, such as time of day, time of year, hormones, physiological and metabolic conditions, habits, diet, etc.
2. To clarify how different processing pipelines or parameters used in the data collection and processing affect the reliability or reproducibility of brain imaging results.
3. To provide new methods and protocols to enhance the reproducibility, such as intensive individual brain imaging, layer fMRI, and multi- or parallel echo sequences.

The scope of this Research Topic is to address and explore which factors affect the reliability and reproducibility of brain imaging results and provide practical perspectives and insights to enhance them. Therefore, we welcome wide scope of article types including but not limited to original research articles, mini or systematic reviews, perspectives, methods, protocols, and letters to the editor.

Keywords: reproducibility, fMRI, E/MEG, fNIRS, PET, MRS, variability


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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