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About this Research Topic

Manuscript Submission Deadline 10 December 2022
Manuscript Extension Submission Deadline 09 February 2023

The oral cavity is the gateway to our body for numerous pathogenic and non-pathogenic microbial species, including bacteria, viruses, fungi, and others. Interestingly, poor oral hygiene coupled to several risk factors, like as tobacco and alcohol use, defects in host immunoregulation, pre-existing systemic ...

The oral cavity is the gateway to our body for numerous pathogenic and non-pathogenic microbial species, including bacteria, viruses, fungi, and others. Interestingly, poor oral hygiene coupled to several risk factors, like as tobacco and alcohol use, defects in host immunoregulation, pre-existing systemic disorders, promotes the proliferation and the dissemination, locally and systemically (i.e. bacteremia), of these pathogenic species along with the release of their toxic factors. For this reason, preventing oral health problems and diseases associated with the perturbation of the oral microbiome (dysbiosis), like caries and periodontitis, is currently considered a strategy to reduce the risk of more severe systemic illnesses, including cancer and cardiovascular disorders.

Understanding the molecular mechanisms involved in these disorders provides the basis for the identification of druggable targets and facilitates the development of novel treatments aimed at preventing the development of both oral and systemic disorders.

The Research Topic aims to provide the readers of Frontiers in Physiology with an update on the most recent findings (clinical and pre-clinical) that support the existence of a relationship between oral dysbiosis and systemic disorders, with particular emphasis on the common risk factors, molecular mechanisms, phenotype, and therapeutical approaches.

This Research Topic welcomes the submission of both original and reviews articles providing the readers of Frontiers in Physiology an update on the following sub-topics:

1. Molecular triggering factors and/or signaling pathways linking oral and systemic disorders
2. Novel therapeutic strategies aimed at targeting oral dysbiosis preventing systemic disorders
3. Clinical evidence that links molecular mechanisms with the pathogenesis of oral and systemic disorders.

Keywords: Oral Health, Microbiome, Dysbiosis, Periodontitis, Caries, Pathophysiology, Systemic, Health, Disease, Cardiac, Neuronal


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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