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Abstract Submission Deadline 18 December 2022
Manuscript Submission Deadline 11 April 2023

Cross-reactivity promotes cross-sensitization of allergic subjects to highly conserved groups of allergens. Cross-reactivity between allergenic sources impacts the diagnosis and development of immunotherapy in patients suffering from allergic diseases.

The study of the cross-reactivity of new allergens by means of in vitro or bioinformatic methods is important for the characterization of homologues in different allergenic sources

The aim of this Research Topic is to contribute to advances in the identification of new allergenic sources with the potential for cross-reactivity with known biological sources. We also aim to provide a platform for discussion of the impact of cross-reactivity in the diagnosis and exacerbation of symptoms in allergic diseases and the development of suitable therapies.

All article types accepted by Frontiers in Allergy are welcome, we particularly encourage the submission of original articles, bioinformatics approaches, reviews and case reports. Suitable themes for manuscripts include, but are not limited to:

• Advances in the characterization of new allergens and sources. New methods (bioinformatic, proteomic, or in vitro) to study cross-reactivity in allergy.
• Epitope mapping to explore cross-reactivity: T-cell versus B-cell (IgE) epitopes.
• Identification of antigenic epitopes involved in cross reactivity among allergens characterized in common allergenic sources.
• The impact of cross-reactivity in allergy diagnosis.
• The advantages cross reactivity in immunotherapy formulation: theorical, experimental and clinical perspectives are welcome.
• Clinical implications of cross reactivity on allergic disease severity
• Formulation of cross-reactive allergens for immunotherapy, exploring pollens, animals, insects and mites.
• A theoretic and practical comparison of the European treatment/formulation approach vs. the approach utilized in the USA (i.e., single vs. multiallergen SCIT).
• Novel practical applications of cross-reactivity utilized in the formulation and therapy of specific disorders such as Occupational Rhinitis.
• Application and development of bioinformatic tools for cross reactivity assessment (original tools or application of conventional tools such as ALLERDB, COMPARE allergen database or AllerTool, for example). We also welcome protocols or proceedings that integrate other bioinformatic tools to study cross reactivity.

Keywords: Allergy, cross reactivity, IgE, bioinformatic, epitope, allergen, proteomic, immunotherapy


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Cross-reactivity promotes cross-sensitization of allergic subjects to highly conserved groups of allergens. Cross-reactivity between allergenic sources impacts the diagnosis and development of immunotherapy in patients suffering from allergic diseases.

The study of the cross-reactivity of new allergens by means of in vitro or bioinformatic methods is important for the characterization of homologues in different allergenic sources

The aim of this Research Topic is to contribute to advances in the identification of new allergenic sources with the potential for cross-reactivity with known biological sources. We also aim to provide a platform for discussion of the impact of cross-reactivity in the diagnosis and exacerbation of symptoms in allergic diseases and the development of suitable therapies.

All article types accepted by Frontiers in Allergy are welcome, we particularly encourage the submission of original articles, bioinformatics approaches, reviews and case reports. Suitable themes for manuscripts include, but are not limited to:

• Advances in the characterization of new allergens and sources. New methods (bioinformatic, proteomic, or in vitro) to study cross-reactivity in allergy.
• Epitope mapping to explore cross-reactivity: T-cell versus B-cell (IgE) epitopes.
• Identification of antigenic epitopes involved in cross reactivity among allergens characterized in common allergenic sources.
• The impact of cross-reactivity in allergy diagnosis.
• The advantages cross reactivity in immunotherapy formulation: theorical, experimental and clinical perspectives are welcome.
• Clinical implications of cross reactivity on allergic disease severity
• Formulation of cross-reactive allergens for immunotherapy, exploring pollens, animals, insects and mites.
• A theoretic and practical comparison of the European treatment/formulation approach vs. the approach utilized in the USA (i.e., single vs. multiallergen SCIT).
• Novel practical applications of cross-reactivity utilized in the formulation and therapy of specific disorders such as Occupational Rhinitis.
• Application and development of bioinformatic tools for cross reactivity assessment (original tools or application of conventional tools such as ALLERDB, COMPARE allergen database or AllerTool, for example). We also welcome protocols or proceedings that integrate other bioinformatic tools to study cross reactivity.

Keywords: Allergy, cross reactivity, IgE, bioinformatic, epitope, allergen, proteomic, immunotherapy


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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