About this Research Topic
Gut microbiota refer to the trillions of microorganisms that colonize the intestinal tract. Microbes hold a symbiotic relationship with the host by contributing to several benefits including, providing beneficial metabolites, protection against pathogen colonization, maintaining the integrity of the mucosal barrier and promoting immune homeostasis. The interaction between commensal microbiota and the mucosal immune system is crucial for proper immune function and an altered gut microbial composition (dysbiosis), has been associated with many inflammatory and immune system-related conditions including but not limited to inflammatory bowel disease (IBD) and cancer. Dysbiosis of gut microbiota can trigger innate and adaptive immune responses associated with inflammation and tumor formation. Additionally, the host pathways involving Toll-like receptors (TLRs) and Nod-like receptors (NLRs) regulate the innate immune system by modulating microbial composition and activating inflammasome-mediated dysbiosis. An understanding of molecular mechanisms involved in these bidirectional host-microbial interactions are critical for developing new therapeutic modalities.
The goal of this collection is to encourage investigators to contribute original articles that investigate a role of perturbed gut microbiota in pathophysiology of inflammatory disorders including cancer. Furthermore, we welcome review articles that summarize the current information and state of understanding of dysbiosis as it relates to inflammation which can lead to better understanding of underlying pathophysiology and potential targeted therapeutic strategies.
The following are suggestions for subtopics. However, this list is not comprehensive, and any related subtopics are welcome.
1. Molecular mechanisms in non-cancer gastrointestinal (GI) inflammatory disorders affecting microbial composition
2. Molecular mechanisms in various GI cancers affecting the microbial composition
3. Epidemiological studies investigating gut microbiota associated with inflammatory disorders
4. Molecular or epidemiologic studies investigating gut microbiota in disorders of immune system and autoimmune diseases.
The goal of this collection is to encourage investigators to contribute original articles that investigate a role of perturbed gut microbiota in pathophysiology of inflammatory disorders including cancer. Furthermore, we welcome review articles that summarize the current information and state of understanding of dysbiosis as it relates to inflammation which can lead to better understanding of underlying pathophysiology and potential targeted therapeutic strategies.
The following are suggestions for subtopics. However, this list is not comprehensive, and any related subtopics are welcome.
1. Molecular mechanisms in non-cancer gastrointestinal (GI) inflammatory disorders affecting microbial composition
2. Molecular mechanisms in various GI cancers affecting the microbial composition
3. Epidemiological studies investigating gut microbiota associated with inflammatory disorders
4. Molecular or epidemiologic studies investigating gut microbiota in disorders of immune system and autoimmune diseases.
Keywords: Microbiome, Inflammatory Gastrointestinal Disorders, Gastrointestinal Cancers, Host-Microbiome Interactions, Dysbiosis
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
