Research Topic

The Role of SR-BI in Carcinogenesis, Metastasis; Emerging Opportunities for Enhanced Diagnosis and Treatment

  • Submission closed.

About this Research Topic

SR-BI is an integral membrane glycoprotein that acts as a HDL-specific receptor and promotes the selective uptake of HDL cholesteryl esters into cells without degradation of lipoprotein structure. The interaction of HDL-like particles with the SR-B1 promotes the bi-directional cholesterol movement between ...

SR-BI is an integral membrane glycoprotein that acts as a HDL-specific receptor and promotes the selective uptake of HDL cholesteryl esters into cells without degradation of lipoprotein structure. The interaction of HDL-like particles with the SR-B1 promotes the bi-directional cholesterol movement between cells and HDL and activates a signal transduction pathway and multiple subsequente kinase cascades and endothelial nitrous oxide synthase (eNOS).

Apart from the vital functions in cellular organisation and stability, cholesterol is thought to assume a preponderant role in the process of carcinogenesis and metastasis. The increased patterns of the SR-B1 receptor expression in several tumour cell lines and the plasmatic profiles of lipoproteins levels in cancer patients corroborate this hypothesis and unveil an new and exciting opportunity in cancer therapy and diagnosis. In this sense the SR-B1 receptor is thought to play a preponderant role in cancer cells by mediating the flow of cholesteryl esters into the cells.

This Frontiers Research Topic will focus on the specific aspects of this receptor-lipoprotein interaction and on how can we explore the selective SR-B1 mediated uptake of HDL’s core components, to deliver therapy directly to cancer cells.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Recent Articles

Loading..

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..

Comments

Loading..

Add a comment

Add comment
Back to top