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About this Research Topic

Manuscript Submission Deadline 13 January 2023
Manuscript Extension Submission Deadline 12 February 2023

Physical activity has physiological, immunological and metabolic effects mainly due to the autocrine, paracrine and endocrine factors (myokines) expressed and released by working muscle fibers. Evidence suggests that physical activity also improves prognosis following cancer diagnosis and increases survival in the long term. Preclinical studies indicate that these effects are mainly due to the potential of exercise in increasing efficacy of radiotherapy and chemotherapy by reducing tumor hypoxia and increasing drug delivery to the tumor site, via increased blood perfusion.

Thus, exercise itself appears to be a critical medicine, synergizing with canonical anti-cancer therapies, however, more research is needed to fully understand the direct and synergistic effects of exercise on cancer. The biology of physical activity is complex and variable affecting multiple organ systems via autocrine, paracrine, and endocrine fashion within a crosstalk network. The understanding of these integrative mechanisms will enhance how physical activity can ultimately influence the risk and prognosis of various cancers. For example, examining the mechanism of myokine-induced cancer suppression in response to different exercise modes, dosages and intensities may further improve exercise prescription in patients with cancer.

This Research Topic will focus on the role of physical activity in human cancer with the aim to highlight the fundamental mechanisms, components and actions of cellular signaling systems and aberrations of the signal transduction processes that may take place in diseased cells. The following basic and pathophysiological topics at the molecule and cell level related to the diseased cells may as well be considered:

• Production of biologically active myokines;
• Actions of muscle hormonally active substances;
• Myokine receptors status and its capacity for therapy;
• Cellular expression of oncogenes functioning as myokines receptor and transducing proteins;
• Identification of the intracellular pathways and the changes in expression of genes involved in exercise-dependent inhibition of cancer cell growth and invasion;
• The impact of exercise on cancer initiation/progression in patients and the analysis of their myokine profiles.
• The relationship of myokines to cancer.

Finally, we also welcome studies aimed at acquiring knowledge towards specific effects of different physical exercise protocols on survival and quality of life in human cancer.

Keywords: Myokines, Cancer, Physical activity, Muscle fibers, Signal transduction, Myokines receptors, Physical exercise protocols


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Physical activity has physiological, immunological and metabolic effects mainly due to the autocrine, paracrine and endocrine factors (myokines) expressed and released by working muscle fibers. Evidence suggests that physical activity also improves prognosis following cancer diagnosis and increases survival in the long term. Preclinical studies indicate that these effects are mainly due to the potential of exercise in increasing efficacy of radiotherapy and chemotherapy by reducing tumor hypoxia and increasing drug delivery to the tumor site, via increased blood perfusion.

Thus, exercise itself appears to be a critical medicine, synergizing with canonical anti-cancer therapies, however, more research is needed to fully understand the direct and synergistic effects of exercise on cancer. The biology of physical activity is complex and variable affecting multiple organ systems via autocrine, paracrine, and endocrine fashion within a crosstalk network. The understanding of these integrative mechanisms will enhance how physical activity can ultimately influence the risk and prognosis of various cancers. For example, examining the mechanism of myokine-induced cancer suppression in response to different exercise modes, dosages and intensities may further improve exercise prescription in patients with cancer.

This Research Topic will focus on the role of physical activity in human cancer with the aim to highlight the fundamental mechanisms, components and actions of cellular signaling systems and aberrations of the signal transduction processes that may take place in diseased cells. The following basic and pathophysiological topics at the molecule and cell level related to the diseased cells may as well be considered:

• Production of biologically active myokines;
• Actions of muscle hormonally active substances;
• Myokine receptors status and its capacity for therapy;
• Cellular expression of oncogenes functioning as myokines receptor and transducing proteins;
• Identification of the intracellular pathways and the changes in expression of genes involved in exercise-dependent inhibition of cancer cell growth and invasion;
• The impact of exercise on cancer initiation/progression in patients and the analysis of their myokine profiles.
• The relationship of myokines to cancer.

Finally, we also welcome studies aimed at acquiring knowledge towards specific effects of different physical exercise protocols on survival and quality of life in human cancer.

Keywords: Myokines, Cancer, Physical activity, Muscle fibers, Signal transduction, Myokines receptors, Physical exercise protocols


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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