Currently, the treatment options for gastrointestinal malignancies mainly include surgery, chemotherapy, radiotherapy, and molecular targeted therapy, etc. Drug therapy is one of the main treatments for patients with advanced stages, but the efficacy of chemotherapy seems to have reached a plateau, and the progress of traditional molecular targeted therapy is relatively slow. In addition, the benefits of the current chemotherapy combined with targeted therapy for patients with advanced stages of gastrointestinal malignancies are still not satisfactory. Tumor immunotherapy is an emerging therapeutic approach and is a current research hotspot, and there are hopes that immunotherapy can help further improve the prognosis and quality of life for patients with gastrointestinal malignancies. At the same time, potential targets of immunotherapeutic drugs and prognostic biomarkers for gastrointestinal malignancies have been less studied than other common cancers, such as lung cancer. Prognostic biomarker studies are the beginning of exploring new drug targets and revealing potential mechanisms of tumor progression.
Immunotherapies, particularly PD1 or PD-L1 antagonists, have demonstrated effective therapeutic efficacy against various types of cancer. To date, many PD1 drugs are available for cancer treatment, and more than 100 PD1 drugs are in clinical trials. However, the question of how to screen sensitive patients and predict the efficacy of immunotherapy remains unresolved. In addition, predictive biomarkers and treatment guidelines for immunotherapy of gastrointestinal malignancies have hardly been studied.
In this research topic, we focus on biomarkers for immunotherapy of gastrointestinal malignancies and the discovery of more predictive or prognostic biomarkers that stratify patients suitable for immunotherapy and indicate the prognosis or immunotherapeutic efficacy of patients with gastrointestinal malignancies.
We welcome submissions of reviews, mini-reviews, systemic reviews and meta-analyses, clinical trials, and original research articles covering, but not limited to, the following topics.
1. New biomarkers to predict the efficacy of immunotherapy for gastrointestinal malignancies.
2. Novel drug targets for immunotherapy of gastrointestinal malignancies.
3. New clinical trials or studies for immunotherapy of gastrointestinal malignancies.
4. Novel immunotherapeutic agents for gastrointestinal malignancies.
5. Basic research on the molecular mechanism of drug resistance in immunotherapy for gastrointestinal malignancies.
Please note: Manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases and not accompanied by validation (independent cohort or in vitro or in vivo biological validation) are beyond the scope of this section and will not be accepted as research topics.
Currently, the treatment options for gastrointestinal malignancies mainly include surgery, chemotherapy, radiotherapy, and molecular targeted therapy, etc. Drug therapy is one of the main treatments for patients with advanced stages, but the efficacy of chemotherapy seems to have reached a plateau, and the progress of traditional molecular targeted therapy is relatively slow. In addition, the benefits of the current chemotherapy combined with targeted therapy for patients with advanced stages of gastrointestinal malignancies are still not satisfactory. Tumor immunotherapy is an emerging therapeutic approach and is a current research hotspot, and there are hopes that immunotherapy can help further improve the prognosis and quality of life for patients with gastrointestinal malignancies. At the same time, potential targets of immunotherapeutic drugs and prognostic biomarkers for gastrointestinal malignancies have been less studied than other common cancers, such as lung cancer. Prognostic biomarker studies are the beginning of exploring new drug targets and revealing potential mechanisms of tumor progression.
Immunotherapies, particularly PD1 or PD-L1 antagonists, have demonstrated effective therapeutic efficacy against various types of cancer. To date, many PD1 drugs are available for cancer treatment, and more than 100 PD1 drugs are in clinical trials. However, the question of how to screen sensitive patients and predict the efficacy of immunotherapy remains unresolved. In addition, predictive biomarkers and treatment guidelines for immunotherapy of gastrointestinal malignancies have hardly been studied.
In this research topic, we focus on biomarkers for immunotherapy of gastrointestinal malignancies and the discovery of more predictive or prognostic biomarkers that stratify patients suitable for immunotherapy and indicate the prognosis or immunotherapeutic efficacy of patients with gastrointestinal malignancies.
We welcome submissions of reviews, mini-reviews, systemic reviews and meta-analyses, clinical trials, and original research articles covering, but not limited to, the following topics.
1. New biomarkers to predict the efficacy of immunotherapy for gastrointestinal malignancies.
2. Novel drug targets for immunotherapy of gastrointestinal malignancies.
3. New clinical trials or studies for immunotherapy of gastrointestinal malignancies.
4. Novel immunotherapeutic agents for gastrointestinal malignancies.
5. Basic research on the molecular mechanism of drug resistance in immunotherapy for gastrointestinal malignancies.
Please note: Manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases and not accompanied by validation (independent cohort or in vitro or in vivo biological validation) are beyond the scope of this section and will not be accepted as research topics.