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About this Research Topic

Manuscript Submission Deadline 01 May 2023

This Research Topic is part of the series dedicated to Hypoxia and Cardiorespiratory Control.

The Topic will showcase the research presented in the 15th Oxford Conference on Modelling and Control of Breathing, October 17-21 (Odawara, Japan).
The respiratory and cardiovascular systems play vitally important roles in maintaining the adequate oxygen level in the body, which is essential for a healthy life. When the oxygen level in the body is not sufficient, i.e., when hypoxia is loaded, the respiratory and cardiovascular systems respond to restore, compensate or adapt to hypoxia, e.g., by increasing ventilation. Traditionally, it has been thought that hypoxia is detected solely in the carotid and aortic bodies, i.e., in the peripheral chemoreceptors, the information from the peripheral chemoreceptors is transmitted to the respiratory and cardiovascular centers in the brainstem and respiratory and cardiovascular neural output is regulated. However, recent progress in neurophysiology has clarified that there are hypoxia-sensing mechanisms not only in the periphery but also in the central nervous system. Although these issues have been actively studied, precise respiratory and cardiovascular responsive mechanisms to hypoxia have not been fully elucidated.

In this article collection, we intend to publish articles describing the physiological mechanisms of respiratory and cardiovascular responses to hypoxia, including the following topics:
- hypoxia–sensing mechanism in the carotid body,
- hypoxia–sensing mechanism in the brain, hypoxia–sensing mechanism in the spinal cord,
- the effect of intermittent hypoxia on the recovery of acute spinal cord injury,
- the effect of hypoxia on the cardiovascular regulation in the brain.

This Research Topic Volume II follows the preceding Topic and will help us further understand the mechanisms of how the respiratory and cardiovascular systems respond to hypoxia to restore, compensate or adapt to hypoxia, and will be the basis of future research, e.g., to develop drugs that facilitate the recovery from hypoxic brain injuries or optimize the hypoxic cardiovascular responses.

Keywords: hypoxia, hypoxia-sensing mechanisms, blood pressure, cardiorespiratory control


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

This Research Topic is part of the series dedicated to Hypoxia and Cardiorespiratory Control.

The Topic will showcase the research presented in the 15th Oxford Conference on Modelling and Control of Breathing, October 17-21 (Odawara, Japan).
The respiratory and cardiovascular systems play vitally important roles in maintaining the adequate oxygen level in the body, which is essential for a healthy life. When the oxygen level in the body is not sufficient, i.e., when hypoxia is loaded, the respiratory and cardiovascular systems respond to restore, compensate or adapt to hypoxia, e.g., by increasing ventilation. Traditionally, it has been thought that hypoxia is detected solely in the carotid and aortic bodies, i.e., in the peripheral chemoreceptors, the information from the peripheral chemoreceptors is transmitted to the respiratory and cardiovascular centers in the brainstem and respiratory and cardiovascular neural output is regulated. However, recent progress in neurophysiology has clarified that there are hypoxia-sensing mechanisms not only in the periphery but also in the central nervous system. Although these issues have been actively studied, precise respiratory and cardiovascular responsive mechanisms to hypoxia have not been fully elucidated.

In this article collection, we intend to publish articles describing the physiological mechanisms of respiratory and cardiovascular responses to hypoxia, including the following topics:
- hypoxia–sensing mechanism in the carotid body,
- hypoxia–sensing mechanism in the brain, hypoxia–sensing mechanism in the spinal cord,
- the effect of intermittent hypoxia on the recovery of acute spinal cord injury,
- the effect of hypoxia on the cardiovascular regulation in the brain.

This Research Topic Volume II follows the preceding Topic and will help us further understand the mechanisms of how the respiratory and cardiovascular systems respond to hypoxia to restore, compensate or adapt to hypoxia, and will be the basis of future research, e.g., to develop drugs that facilitate the recovery from hypoxic brain injuries or optimize the hypoxic cardiovascular responses.

Keywords: hypoxia, hypoxia-sensing mechanisms, blood pressure, cardiorespiratory control


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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