Research Topic

Pancreatic β-cell identity

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Insulin secretion is essential for the normal regulation of glucose homeostasis in al mammals including man. The functional “identity” of the pancreatic β-cell – the sole source of circulating insulin - is defined by a defined secretory response to nutrients and underpinned by a specific gene expression ...

Insulin secretion is essential for the normal regulation of glucose homeostasis in al mammals including man. The functional “identity” of the pancreatic β-cell – the sole source of circulating insulin - is defined by a defined secretory response to nutrients and underpinned by a specific gene expression signature. β-cell identity is thus seen as an increasingly important feature of these cells, which is acquired during the normal development of the endocrine pancreas and may be compromised in disease, notably type 2 diabetes [1], a condition affecting ~8% of the adult population worldwide. On the other, emerging data suggest that, under suitable circumstances, β-cell identity may achieved by non β-cells in the face of the immune-mediated loss of the original β-cell population in Type 1 diabetes.

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