About this Research Topic
Brief background information on the area of research to give context to the Research Topic. The RNA field is in a fast discovery state due to the recent advancements in RNA-based technologies, such as delivery, stability, and computational algorithms. These novel technological tools combined with genetic and molecular studies have been influential in discovering RNA networks that directly impact gene expression and function in healthy and diseased states. The role of RNA binding proteins in regulating RNA networks is emerging as a critical step for gene regulation. Dysregulation of RNA binding proteins is associated with many human diseases, such as amyotrophic lateral sclerosis (ALS), frontotemporal lobar dementia (FTLD), Myotonic Dystrophy, and cancer to name a few. RNA binding protein mutations are associated with congenital heart defects and cardiomyopathies. Dysregulation of RNA binding proteins is implicated in diabetic heart disease, atherosclerosis, cardiac fibrosis, cardiac hypertrophy, and heart failure. This Topic aims to spotlight research centered on how RNA binding proteins and RNA regulatory networks contribute to heart development, pathogenesis of cardiovascular diseases and to explore novel research on the role of RNA binding proteins in healthy and diseased states.
The goals of this topic are to provide new information about RNA binding proteins and their role in human diseases, as well as describing uncharacterized RNA binding proteins and their tissue specific roles and targets. This topic welcomes research on recent advances in resources or methodologies for identification of RNA binding protein targets in tissues, as well as research that provides information about novel therapies that target RNA binding proteins or specific targets of these RNA binding proteins.
• New and improved methodologies about RNA binding protein target identification in tissues
• Machine learning to predict RNA binding protein functions or targets within heart and cardiovascular diseases
• Identification of tissue specific roles and functions of uncharacterized RNA binding proteins
• Mechanistic studies about RNA binding proteins and their contributions to heart development and cardiovascular disease
• RNA based therapies targeting RNA binding proteins or their target RNAs to combat heart and cardiovascular disease
The goals of this topic are to provide new information about RNA binding proteins and their role in human diseases, as well as describing uncharacterized RNA binding proteins and their tissue specific roles and targets. This topic welcomes research on recent advances in resources or methodologies for identification of RNA binding protein targets in tissues, as well as research that provides information about novel therapies that target RNA binding proteins or specific targets of these RNA binding proteins.
• New and improved methodologies about RNA binding protein target identification in tissues
• Machine learning to predict RNA binding protein functions or targets within heart and cardiovascular diseases
• Identification of tissue specific roles and functions of uncharacterized RNA binding proteins
• Mechanistic studies about RNA binding proteins and their contributions to heart development and cardiovascular disease
• RNA based therapies targeting RNA binding proteins or their target RNAs to combat heart and cardiovascular disease
Keywords: RNA binding proteins, heart development, dysregulation, RNA regulatory networks, RNA binding protein functions
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
