Research Topic

From MCI to NCD: Diagnostic Conundrum Embedded in Multi-Scale Modularity

About this Research Topic

In 1997, Freeman Dyson postulated two categories of scientific revolution in his book «Imagined Worlds». One kind is a concept-driven revolution, allowing us to explain "old things in new ways"; another kind is tool-driven revolution, allowing us to discover "new things that have to be explained". Twenty years later, this perspective still sheds new light on the clinical challenges to diagnosing neurodegenerative disease at early stage. In the newly updated Diagnostic and Statistical Manual of Mental Disorders fifth edition (DSM-5), the well-established mild cognitive impairment category (MCI) was replaced with neurocognitive disorders (NCD) to describe a high-risk state for progression to clinical dementia.

Yet, this concept-driven revolution raises a series of questions. Could traditional assessment tools still be sufficient to evaluate the cognitive function with a proper scale? Can neuroimaging characteristics differentiate and explain the cognitive pattern in a different way? Multiple modalities with different measurement scales (e.g., clinical interview, neuropsychological batteries, neuroimaging etc.) may guide us to better understanding of the evolved concept (from MCI to NCD) and then to achieve a more precise diagnosis.

Undoubtedly, there is an emerging need to enhance the sensitivity and specificity of screening and diagnostic tools for DSM-5mild NCD and its main subtypes. This research topic has a wide scope and intends to bring together clinical doctors and psychologists across the areas of neuropsychology, neuroscience, aging and dementia. The contributors are encouraged to submit research articles, reviews, mini-reviews, clinical case studies, short communications as well as theoretical papers relevant to this theme that will discuss this topic from the point of view of these different disciplines relevant to this topic.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

In 1997, Freeman Dyson postulated two categories of scientific revolution in his book «Imagined Worlds». One kind is a concept-driven revolution, allowing us to explain "old things in new ways"; another kind is tool-driven revolution, allowing us to discover "new things that have to be explained". Twenty years later, this perspective still sheds new light on the clinical challenges to diagnosing neurodegenerative disease at early stage. In the newly updated Diagnostic and Statistical Manual of Mental Disorders fifth edition (DSM-5), the well-established mild cognitive impairment category (MCI) was replaced with neurocognitive disorders (NCD) to describe a high-risk state for progression to clinical dementia.

Yet, this concept-driven revolution raises a series of questions. Could traditional assessment tools still be sufficient to evaluate the cognitive function with a proper scale? Can neuroimaging characteristics differentiate and explain the cognitive pattern in a different way? Multiple modalities with different measurement scales (e.g., clinical interview, neuropsychological batteries, neuroimaging etc.) may guide us to better understanding of the evolved concept (from MCI to NCD) and then to achieve a more precise diagnosis.

Undoubtedly, there is an emerging need to enhance the sensitivity and specificity of screening and diagnostic tools for DSM-5mild NCD and its main subtypes. This research topic has a wide scope and intends to bring together clinical doctors and psychologists across the areas of neuropsychology, neuroscience, aging and dementia. The contributors are encouraged to submit research articles, reviews, mini-reviews, clinical case studies, short communications as well as theoretical papers relevant to this theme that will discuss this topic from the point of view of these different disciplines relevant to this topic.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

01 December 2017 Manuscript
01 January 2018 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

01 December 2017 Manuscript
01 January 2018 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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