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About this Research Topic

Abstract Submission Deadline 28 February 2023
Manuscript Submission Deadline 30 June 2023

Neurodegenerative disorders (NDDs) affect approximately 50 million in the US each year. NDDs cause significant disability, and negatively impact the quality of life and health outcomes for both the patient and the caregiver(s).

Non-motor symptoms are often the main cause of institutionalization , causing a large expense on the healthcare system. Most common non-motor symptoms include sleep disturbances, autonomic disturbances (such as orthostatic hypotension), cognitive, behavioral, neuropsychiatric alterations, as well as inflammatory and olfaction alterations.

It is well established that patients often develop non-motor symptoms around 10-15 years prior to diagnosis. Up to now, it is still unclear how to predict the rate of conversion from non-motor symptoms’ complaints to the NDD diagnosis later.

A better understanding of how and which non-motor complaints predict specific NDDs could provide a window for studying the natural history of the specific disease. This is also essential when it comes to aiming to develop and further improve early-stage targeted therapeutics that ultimately reflect on the expenses and the associated burden suffered by patients.

Considering the current knowledge and therapeutic approach toward NDDs, this Research Topic aims to broaden our understanding and provide useful tools linking non-motor symptoms to NDD later appearance in patients complaining of sleep disturbances, autonomic, behavioral, and cognitive disturbances, or presenting inflammation and olfaction abnormalities.

The goal is to:

1) highlight non-motor symptoms associated with specific neurodegenerative diseases
2) establish the predictive value of individual non-motor symptoms to differentiate between neurodegenerative diseases
3) provide a better understanding of the underlying etiology of the specific disease through a neuroanatomic correlation of the non-motor symptoms
4) understand the difference between predictive and prodromal symptoms of neurodegeneration

We welcome articles investigating on the vast range of non-motor symptoms of neurodegeneration, both intended as predictors and prodromal factors. Articles related to neurodegeneration or to specific neurological diseases are welcome. Submissions should highlight non-motor symptoms even when compared to motor symptoms.
Research focused on healthy elderly is also encouraged with a mindset of identifying contributors to sustained healthy aging vs early neurodegenerative processes.

Keywords: Sleep, autonomic, cognition, inflammation, olfaction, gastrointestinal changes, metabolism, behavior, neuropsychiatric


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Neurodegenerative disorders (NDDs) affect approximately 50 million in the US each year. NDDs cause significant disability, and negatively impact the quality of life and health outcomes for both the patient and the caregiver(s).

Non-motor symptoms are often the main cause of institutionalization , causing a large expense on the healthcare system. Most common non-motor symptoms include sleep disturbances, autonomic disturbances (such as orthostatic hypotension), cognitive, behavioral, neuropsychiatric alterations, as well as inflammatory and olfaction alterations.

It is well established that patients often develop non-motor symptoms around 10-15 years prior to diagnosis. Up to now, it is still unclear how to predict the rate of conversion from non-motor symptoms’ complaints to the NDD diagnosis later.

A better understanding of how and which non-motor complaints predict specific NDDs could provide a window for studying the natural history of the specific disease. This is also essential when it comes to aiming to develop and further improve early-stage targeted therapeutics that ultimately reflect on the expenses and the associated burden suffered by patients.

Considering the current knowledge and therapeutic approach toward NDDs, this Research Topic aims to broaden our understanding and provide useful tools linking non-motor symptoms to NDD later appearance in patients complaining of sleep disturbances, autonomic, behavioral, and cognitive disturbances, or presenting inflammation and olfaction abnormalities.

The goal is to:

1) highlight non-motor symptoms associated with specific neurodegenerative diseases
2) establish the predictive value of individual non-motor symptoms to differentiate between neurodegenerative diseases
3) provide a better understanding of the underlying etiology of the specific disease through a neuroanatomic correlation of the non-motor symptoms
4) understand the difference between predictive and prodromal symptoms of neurodegeneration

We welcome articles investigating on the vast range of non-motor symptoms of neurodegeneration, both intended as predictors and prodromal factors. Articles related to neurodegeneration or to specific neurological diseases are welcome. Submissions should highlight non-motor symptoms even when compared to motor symptoms.
Research focused on healthy elderly is also encouraged with a mindset of identifying contributors to sustained healthy aging vs early neurodegenerative processes.

Keywords: Sleep, autonomic, cognition, inflammation, olfaction, gastrointestinal changes, metabolism, behavior, neuropsychiatric


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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