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About this Research Topic

Abstract Submission Deadline 10 December 2022
Manuscript Submission Deadline 10 March 2023

The dysfunction of T cells is the main cause of the failure of T cells to eradicate tumor cells in the tumor microenvironment. Senescent T cells, with defects in proliferation and effector functions, accumulate in aging, chronic viral infections, and autoimmune disorders where antigen stimulation persists. These cells are highly inflammatory and secrete cytotoxic mediators and express natural killer cell receptors by passing their antigen specificity. Increasing evidence suggests that inducing T cell senescence is a key strategy used by malignant tumors to evade immune surveillance. Increasing evidence suggests a link between T cell senescence and tumor progression. Several studies have indicated that the tumor microenvironment promotes the senescence of T cells through multiple pathways. The accumulation of senescent T cells may be responsible for advanced cancer and the low response rate to chemo(radio)therapy as well as immunotherapy. Thus, preventing and restoring T cell senescence could be novel therapeutic strategies for cancer treatment.

In this Research Topic, we will summarize the general features, functional regulation, and signaling network of senescent T cells in tumor development and highlight their potential as prognostic biomarkers in multiple cancer treatments, including chemotherapy, radiotherapy, and immunotherapy. Moreover, we discuss possible therapeutic strategies for preventing or rejuvenating senescence in tumor-specific T cells. Understanding these critical issues may provide novel strategies to enhance cancer immunotherapy.

The aim of this Research Topic is to cover promising, recent, and novel research trends in the regulation of senescent T cells and their use as a potential therapeutic strategy for cancer treatment. This Research Topic will focus on the characterization of senescent T cells, their role in tumor patients, and their potential use as a therapeutic strategy for cancer treatment.

We especially welcome article submissions and encourage contributors to address the following themes (but are not limited to):

•Senescent T cell characterization (phenotyping, pathways, function, regulation…)
•Different types of tumors (solid, AML…)
•Tumor microenvironment (cells, cytokine, interactions)
•Cancer treatments (chemotherapy, radiotherapy, and immunotherapy including CAR T cells)
•Prognostic biomarkers
•Therapeutic strategies for preventing or rejuvenating tumor-specific T cells.

The interested manuscripts could be reviews or data experiments.

Keywords: T cells, senescence, aging, cancer, immunotherapy


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

The dysfunction of T cells is the main cause of the failure of T cells to eradicate tumor cells in the tumor microenvironment. Senescent T cells, with defects in proliferation and effector functions, accumulate in aging, chronic viral infections, and autoimmune disorders where antigen stimulation persists. These cells are highly inflammatory and secrete cytotoxic mediators and express natural killer cell receptors by passing their antigen specificity. Increasing evidence suggests that inducing T cell senescence is a key strategy used by malignant tumors to evade immune surveillance. Increasing evidence suggests a link between T cell senescence and tumor progression. Several studies have indicated that the tumor microenvironment promotes the senescence of T cells through multiple pathways. The accumulation of senescent T cells may be responsible for advanced cancer and the low response rate to chemo(radio)therapy as well as immunotherapy. Thus, preventing and restoring T cell senescence could be novel therapeutic strategies for cancer treatment.

In this Research Topic, we will summarize the general features, functional regulation, and signaling network of senescent T cells in tumor development and highlight their potential as prognostic biomarkers in multiple cancer treatments, including chemotherapy, radiotherapy, and immunotherapy. Moreover, we discuss possible therapeutic strategies for preventing or rejuvenating senescence in tumor-specific T cells. Understanding these critical issues may provide novel strategies to enhance cancer immunotherapy.

The aim of this Research Topic is to cover promising, recent, and novel research trends in the regulation of senescent T cells and their use as a potential therapeutic strategy for cancer treatment. This Research Topic will focus on the characterization of senescent T cells, their role in tumor patients, and their potential use as a therapeutic strategy for cancer treatment.

We especially welcome article submissions and encourage contributors to address the following themes (but are not limited to):

•Senescent T cell characterization (phenotyping, pathways, function, regulation…)
•Different types of tumors (solid, AML…)
•Tumor microenvironment (cells, cytokine, interactions)
•Cancer treatments (chemotherapy, radiotherapy, and immunotherapy including CAR T cells)
•Prognostic biomarkers
•Therapeutic strategies for preventing or rejuvenating tumor-specific T cells.

The interested manuscripts could be reviews or data experiments.

Keywords: T cells, senescence, aging, cancer, immunotherapy


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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