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About this Research Topic

Manuscript Submission Deadline 06 March 2023

Chronic liver disease (CLD) is a progressive liver disease. The pathophysiology of the disease is manifested by increased and continuous inflammation, deterioration of liver functions, distortion of architect of liver tissue, formation of regeneration nodules and progression of hepatic fibrosis which leads to cirrhosis.

Multiple etiologies contribute to CLD and its progression and some of the common etiologies are; Non-alcoholic fatty liver disease (NAFLD), Non-alcoholic steatohepatitis (NASH), Alcohol-associated liver disease (ALD), Viral hepatitis and autoimmune liver diseases.

Furthermore, cirrhotic patients often develop extrahepatic complications which are culminated into multi-organ failure involving kidney, heart, lungs, and other organ systems. Therefore, it is important to understand the molecular mechanism and genetic factors which can contribute towards the progression of the disease.

Within this Research Topic, we aim to foster insights on various etiologies contributing towards the progression chronic liver disease and the multi-organ crosstalk which is often clinically associated with advanced liver disease.

Sub themes for this Research Topic may include, but not limited to:
- Novel techniques (e.g., single-cell sequencing combined with genomics, proteomics, metabolome) revealing mechanisms underlying the progression and multiorgan crosstalk during CLD
-Multiomics studies to identify the diagnosis and prognosis of CLD
- Molecular pathways manifesting the etiologies (such as ALD, NAFLD/NASH, TASH, Viral Hepatitis, autoimmune liver disease) leading CLD
-Translational studies and newly developed evaluation techniques.
-Impact of SARS-COV-2 on the progression of CLD
-Potential therpapeutics for advanced stages of the liver disease progression.

Keywords: Alcohol-associated liver disease (ALD), Non-alcoholic steatohepatitis (NASH), Acute-on-chronic liver failure (ACLF), Hepatotoxicity, Organ failure, Hepatitis


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Chronic liver disease (CLD) is a progressive liver disease. The pathophysiology of the disease is manifested by increased and continuous inflammation, deterioration of liver functions, distortion of architect of liver tissue, formation of regeneration nodules and progression of hepatic fibrosis which leads to cirrhosis.

Multiple etiologies contribute to CLD and its progression and some of the common etiologies are; Non-alcoholic fatty liver disease (NAFLD), Non-alcoholic steatohepatitis (NASH), Alcohol-associated liver disease (ALD), Viral hepatitis and autoimmune liver diseases.

Furthermore, cirrhotic patients often develop extrahepatic complications which are culminated into multi-organ failure involving kidney, heart, lungs, and other organ systems. Therefore, it is important to understand the molecular mechanism and genetic factors which can contribute towards the progression of the disease.

Within this Research Topic, we aim to foster insights on various etiologies contributing towards the progression chronic liver disease and the multi-organ crosstalk which is often clinically associated with advanced liver disease.

Sub themes for this Research Topic may include, but not limited to:
- Novel techniques (e.g., single-cell sequencing combined with genomics, proteomics, metabolome) revealing mechanisms underlying the progression and multiorgan crosstalk during CLD
-Multiomics studies to identify the diagnosis and prognosis of CLD
- Molecular pathways manifesting the etiologies (such as ALD, NAFLD/NASH, TASH, Viral Hepatitis, autoimmune liver disease) leading CLD
-Translational studies and newly developed evaluation techniques.
-Impact of SARS-COV-2 on the progression of CLD
-Potential therpapeutics for advanced stages of the liver disease progression.

Keywords: Alcohol-associated liver disease (ALD), Non-alcoholic steatohepatitis (NASH), Acute-on-chronic liver failure (ACLF), Hepatotoxicity, Organ failure, Hepatitis


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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