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About this Research Topic

Manuscript Submission Deadline 20 January 2023

With the deepening of research, more and more stem cells are used to treat nervous system diseases. However, the therapeutic mechanism of stem cells is not only stem cell proliferation and differentiation but also its paracrine effect. This research topic aims to study the therapeutic effect and mechanism of neural stem cell (NSC)-derived exosomes on nervous system diseases, and to provide a possible therapeutic strategy for non-cellular therapy. In the current study, researchers found that NSC-derived exosomes could promote the survival, proliferation, and differentiation of endogenous NSC and has a specific curative effect on nervous system diseases such as ischemic stroke, Parkinson's disease, and Alzheimer's disease. In addition, the researchers found that exosomes derived from neural stem cells were more effective in treating ischemic stroke than exosomes derived from mesenchymal stem cells. As the mechanism of NSC-derived exosomes has not been clarified, the current lab results are insufficient to support their use in the further clinical study. This research topic aims to explore the contents, biological characteristics, and secretion mechanisms of NSC-derived exosomes, as well as the therapeutic effect and molecular mechanisms of NSC-derived exosomes in various nervous system diseases. In this research topic, we focus on applying NSC-derived exosomes in various nervous system diseases and clarify the contents, biological characteristics, secretion modes, and molecular mechanisms of NSC-derived exosomes to lay a foundation for further clinical study of NSC-derived exosomes.

The following aspects of NSC-derived exosomes are focused:

(1) the molecular structure and components of NSC-derived exosomes; (2) the regulatory effect and mechanisms of NSC-derived exosomes on the microenvironment, endogenous NSC, or other nerve cells;

(3) the therapeutic effect and mechanisms of NSC-derived exosomes on various nervous system diseases;

(4) Engineered NSC-derived exosomes as a drug delivery system for treating various nervous system diseases.

Keywords: Neural stem cells, Exosomes, Nervous system diseases, Non-cellular therapy, Regenerative Medicine


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

With the deepening of research, more and more stem cells are used to treat nervous system diseases. However, the therapeutic mechanism of stem cells is not only stem cell proliferation and differentiation but also its paracrine effect. This research topic aims to study the therapeutic effect and mechanism of neural stem cell (NSC)-derived exosomes on nervous system diseases, and to provide a possible therapeutic strategy for non-cellular therapy. In the current study, researchers found that NSC-derived exosomes could promote the survival, proliferation, and differentiation of endogenous NSC and has a specific curative effect on nervous system diseases such as ischemic stroke, Parkinson's disease, and Alzheimer's disease. In addition, the researchers found that exosomes derived from neural stem cells were more effective in treating ischemic stroke than exosomes derived from mesenchymal stem cells. As the mechanism of NSC-derived exosomes has not been clarified, the current lab results are insufficient to support their use in the further clinical study. This research topic aims to explore the contents, biological characteristics, and secretion mechanisms of NSC-derived exosomes, as well as the therapeutic effect and molecular mechanisms of NSC-derived exosomes in various nervous system diseases. In this research topic, we focus on applying NSC-derived exosomes in various nervous system diseases and clarify the contents, biological characteristics, secretion modes, and molecular mechanisms of NSC-derived exosomes to lay a foundation for further clinical study of NSC-derived exosomes.

The following aspects of NSC-derived exosomes are focused:

(1) the molecular structure and components of NSC-derived exosomes; (2) the regulatory effect and mechanisms of NSC-derived exosomes on the microenvironment, endogenous NSC, or other nerve cells;

(3) the therapeutic effect and mechanisms of NSC-derived exosomes on various nervous system diseases;

(4) Engineered NSC-derived exosomes as a drug delivery system for treating various nervous system diseases.

Keywords: Neural stem cells, Exosomes, Nervous system diseases, Non-cellular therapy, Regenerative Medicine


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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