Research Topic

The Role of AAA+ Proteins in Protein Repair and Degradation

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ATPases Associated with diverse cellular Activities (AAA+) is a superfamily of proteins that carry out a large variety of functions essential to cell physiology, including control of protein homeostasis, DNA replication, recombination, chromatin remodeling, ribosomal RNA processing, molecular targeting, ...

ATPases Associated with diverse cellular Activities (AAA+) is a superfamily of proteins that carry out a large variety of functions essential to cell physiology, including control of protein homeostasis, DNA replication, recombination, chromatin remodeling, ribosomal RNA processing, molecular targeting, organelle biogenesis, and membrane fusion. Members of this superfamily are defined by the presence of what is termed the AAA+ domain containing the canonical Walker A and B motifs required for ATP binding and hydrolysis. They typically form hexameric complexes and act as motors to remodel other proteins, DNA/RNA, or multicomponent complexes. Indeed, many chaperones and ATP-dependent proteases are or have subunits that belong to this superfamily.

There has been substantial progress in identifying the structure and mechanism of function of a large number of AAA+ proteins. In this series, a detailed structural and biochemical view is provided of several AAA+ chaperones and proteases, namely: ClpXP, ClpAPS, ClpB and Hsp104, FtsH, 19S proteasome, Lon, p97, Pex1/6, CbbQ, torsin, and NSF.

Contributors are encouraged to submit perspectives, reviews, and original research articles.


Keywords: AAA+ proteins, Molecular chaperones, ATP-dependent degradation, Protein folding, Protein degradation, Structure, Function


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