Research Topic

The Developmental and Functional Interplay between Macrophages and Erythrocytes

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Throughout development macrophages and erythroid cells co-develop and are functionally interdependent. In the yolk sac, recently described erythroid myeloid progenitors (EMPs) develop into the first wave of definitive erythroid cells and also produce long lived, self-renewing populations of tissue resident ...

Throughout development macrophages and erythroid cells co-develop and are functionally interdependent. In the yolk sac, recently described erythroid myeloid progenitors (EMPs) develop into the first wave of definitive erythroid cells and also produce long lived, self-renewing populations of tissue resident macrophages. Later during development, definitive erythrocytes develop from erythroblastic islands, where reciprocal interactions between erythroid progenitors and the central macrophage drive enucleation and terminal differentiation. At the other end of their life span, senescent or damaged erythrocytes are removed from circulation by red pulp macrophages, which recycle heme and iron for future erythropoiesis. Finally, recent studies indicate that macrophages play an important role in the process of stress erythropoiesis in the spleen, and in the development of anemia in response to inflammation. This Research Topic will cover each of these processes in detail to provide an overall view of the role of macrophages in erythrocyte development under conditions of homeostasis


Keywords: erythroblastic islands, erythromyeloid progenitors, tissue resident macrophages, iron recycling, macrophages, erythrocytes


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