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Manuscript Submission Deadline 24 April 2023

Cardiovascular diseases (CVD) are the leading cause of morbidity and mortality for both males and females across the world and a huge economic burden for the society and healthcare system. CVDs have a significant relationship with aging. Recently, CVD prevalence is also rapidly increasing in low and middle-income countries, where the limited identification and treatment options led to frequent unreported cases that lead to early death. Although recent two decades considerable improvement has been made in the management of CVD patients but is still an urgent need for novel diagnostic and prognostic biomarkers, and newer noninvasive, relatively cheaper, and easily available evidence-based therapeutic interventions to decline the incidence of this disease.

Microribonucleic acids (miRNAs) are short, endogenous, highly specific, single-stranded, non-coding RNAs that post-transcriptionally repress translation or induce mRNA degradation of target transcripts through sequence-specific binding. Moreover, miRNAs target hundreds of transcripts to regulate diverse biological pathways and processes, including biological aging. Several studies demonstrated that various plasma miRNAs have remarkable up and down-regulated in middle age and elderly people and relationship with CVD.

It has been acknowledged that miRNAs are critically regulated in all the cardiovascular biological processes and deregulated vascular enriched miRNAs are directly associated with various cardiovascular diseases including atherosclerosis, hypertension, cardiomyopathy, ischemic heart diseases, atrial fibrillation, heart failure, and stroke. Recent various clinical studies recommended that several cardiac-specific circulatory miRNAs have a significant impact on diagnosis and therapeutic strategy but still it is in the primary stage and needs further studies to establish their clinical role in human beings.

The aim of this special issue is to invite investigators to contribute the original research articles, and clinical trials as well as review articles about the discovery of novel clinical biomarkers and advanced therapies of miRNAs for cardiovascular diseases and their association with aging.

Potential topics include but are not limited to the following:
1) Plasma miRNAs as a novel biomarker for early identification of cardiovascular diseases.
2) The miRNAs correlated with aging.
3) The miRNAs and cardiovascular risk factors (smoking, dyslipidemia, pre-diabetes/diabetes, uncontrolled blood pressure, obesity).
4) The updated technologies to detect body fluid miRNAs in the field of integrated biomarker assessment and qualification in the context of diagnosis, prognosis, treatment, and prevention of cardiovascular diseases.
5) The miRNAs and hypertension.
6) The miRNAs and atherosclerosis.
7) The miRNAs linked with endothelial and cardiomyocyte injury.
8) The therapeutic effect of miRNAs in cardiovascular diseases.

Keywords: cardiovascular aging, microRNAs, miRNAs, cardiovascular disease, vascular aging


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Cardiovascular diseases (CVD) are the leading cause of morbidity and mortality for both males and females across the world and a huge economic burden for the society and healthcare system. CVDs have a significant relationship with aging. Recently, CVD prevalence is also rapidly increasing in low and middle-income countries, where the limited identification and treatment options led to frequent unreported cases that lead to early death. Although recent two decades considerable improvement has been made in the management of CVD patients but is still an urgent need for novel diagnostic and prognostic biomarkers, and newer noninvasive, relatively cheaper, and easily available evidence-based therapeutic interventions to decline the incidence of this disease.

Microribonucleic acids (miRNAs) are short, endogenous, highly specific, single-stranded, non-coding RNAs that post-transcriptionally repress translation or induce mRNA degradation of target transcripts through sequence-specific binding. Moreover, miRNAs target hundreds of transcripts to regulate diverse biological pathways and processes, including biological aging. Several studies demonstrated that various plasma miRNAs have remarkable up and down-regulated in middle age and elderly people and relationship with CVD.

It has been acknowledged that miRNAs are critically regulated in all the cardiovascular biological processes and deregulated vascular enriched miRNAs are directly associated with various cardiovascular diseases including atherosclerosis, hypertension, cardiomyopathy, ischemic heart diseases, atrial fibrillation, heart failure, and stroke. Recent various clinical studies recommended that several cardiac-specific circulatory miRNAs have a significant impact on diagnosis and therapeutic strategy but still it is in the primary stage and needs further studies to establish their clinical role in human beings.

The aim of this special issue is to invite investigators to contribute the original research articles, and clinical trials as well as review articles about the discovery of novel clinical biomarkers and advanced therapies of miRNAs for cardiovascular diseases and their association with aging.

Potential topics include but are not limited to the following:
1) Plasma miRNAs as a novel biomarker for early identification of cardiovascular diseases.
2) The miRNAs correlated with aging.
3) The miRNAs and cardiovascular risk factors (smoking, dyslipidemia, pre-diabetes/diabetes, uncontrolled blood pressure, obesity).
4) The updated technologies to detect body fluid miRNAs in the field of integrated biomarker assessment and qualification in the context of diagnosis, prognosis, treatment, and prevention of cardiovascular diseases.
5) The miRNAs and hypertension.
6) The miRNAs and atherosclerosis.
7) The miRNAs linked with endothelial and cardiomyocyte injury.
8) The therapeutic effect of miRNAs in cardiovascular diseases.

Keywords: cardiovascular aging, microRNAs, miRNAs, cardiovascular disease, vascular aging


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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