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About this Research Topic

Manuscript Submission Deadline 30 April 2023

Wound healing is a complex process orchestrated by a variety of known and unknown factors, divided into four stages (haemostasis, inflammation, proliferation, and remodeling) that occur in both skin and oral tissues. However, oral tissues present special features such as rapid wound closure and reduced scar formation. Non-surgical and surgical therapy of periodontal and peri-implant diseases generate different types of wounds. Since the wound repair process is critical to achieving successful treatment outcomes, increasing understanding of the extrinsic and intrinsic characteristics of the healing process of periodontal and peri-implant soft tissues appears to be of paramount importance.

An extraordinary volume of work has been done in recent years to understand the healing of periodontal and peri-implant wounds. Numerous studies are published presenting new biomaterials and therapies which allowed improvements over existing treatments that impact wound repair and regeneration. However, valuable information on the healing of periodontal and peri-implant soft tissues, from a histological, molecular, and clinical point of view, is still lacking and many of the mechanisms underlying these fundamental processes need to be elucidated.

This Research Topic will include basic science, original clinical research, or review articles that provide relevant information, describe important new findings, and critically analyze current knowledge on periodontal and peri-implant soft tissue wound healing, discussing the effort to develop new approaches to improve soft tissue repair tissue. Potential topics include but are not limited to the following:

• Current concepts on periodontal and peri-implant soft tissue wound healing
• New evidence on oral soft tissue wound repair using small and large animal models
• Differential intrinsic characteristics of periodontal and peri-implant soft tissue wound healing using in vitro or in vivo approaches
• In vitro and in vivo studies evaluating components of the extracellular matrix (mainly hyaluronan), cellular response and interactions, growth factors, integrins, cytokines, differentially expressed genes, and protein expression in wound healing of periodontal and peri-implant soft tissues
• Crosstalk between connective tissue cells (mainly fibroblasts/myofibroblasts), inflammatory cells, protein expression, and clinical behavior in the healing of periodontal and peri-implant soft tissue wounds
• Recent advances in gene expression profiling and proteomic analysis to deepen and understand the soft tissue response after non-surgical and surgical treatment of periodontal and peri-implant diseases
• Development of adjunctive therapies for the non-surgical treatment of periodontal and peri-implant disease in order to optimize the healing of periodontal and peri-implant soft tissues
• New surgical approaches, including the use of biomaterials and biomodulators as adjunctive treatment, to promote healing of periodontal and peri-implant soft tissues
• Novel methods to monitor and evaluate wound healing of periodontal and peri-implant soft tissues

Keywords: Dental Implants, Peri-Implantitis, Periodontics, Periodontitis, Surgical Wound, Wound Healing


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Wound healing is a complex process orchestrated by a variety of known and unknown factors, divided into four stages (haemostasis, inflammation, proliferation, and remodeling) that occur in both skin and oral tissues. However, oral tissues present special features such as rapid wound closure and reduced scar formation. Non-surgical and surgical therapy of periodontal and peri-implant diseases generate different types of wounds. Since the wound repair process is critical to achieving successful treatment outcomes, increasing understanding of the extrinsic and intrinsic characteristics of the healing process of periodontal and peri-implant soft tissues appears to be of paramount importance.

An extraordinary volume of work has been done in recent years to understand the healing of periodontal and peri-implant wounds. Numerous studies are published presenting new biomaterials and therapies which allowed improvements over existing treatments that impact wound repair and regeneration. However, valuable information on the healing of periodontal and peri-implant soft tissues, from a histological, molecular, and clinical point of view, is still lacking and many of the mechanisms underlying these fundamental processes need to be elucidated.

This Research Topic will include basic science, original clinical research, or review articles that provide relevant information, describe important new findings, and critically analyze current knowledge on periodontal and peri-implant soft tissue wound healing, discussing the effort to develop new approaches to improve soft tissue repair tissue. Potential topics include but are not limited to the following:

• Current concepts on periodontal and peri-implant soft tissue wound healing
• New evidence on oral soft tissue wound repair using small and large animal models
• Differential intrinsic characteristics of periodontal and peri-implant soft tissue wound healing using in vitro or in vivo approaches
• In vitro and in vivo studies evaluating components of the extracellular matrix (mainly hyaluronan), cellular response and interactions, growth factors, integrins, cytokines, differentially expressed genes, and protein expression in wound healing of periodontal and peri-implant soft tissues
• Crosstalk between connective tissue cells (mainly fibroblasts/myofibroblasts), inflammatory cells, protein expression, and clinical behavior in the healing of periodontal and peri-implant soft tissue wounds
• Recent advances in gene expression profiling and proteomic analysis to deepen and understand the soft tissue response after non-surgical and surgical treatment of periodontal and peri-implant diseases
• Development of adjunctive therapies for the non-surgical treatment of periodontal and peri-implant disease in order to optimize the healing of periodontal and peri-implant soft tissues
• New surgical approaches, including the use of biomaterials and biomodulators as adjunctive treatment, to promote healing of periodontal and peri-implant soft tissues
• Novel methods to monitor and evaluate wound healing of periodontal and peri-implant soft tissues

Keywords: Dental Implants, Peri-Implantitis, Periodontics, Periodontitis, Surgical Wound, Wound Healing


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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