About this Research Topic
The research on replication origins is important not only in providing insights into the structure and function of the replication origins but also in understanding the regulatory mechanisms of the initiation step in DNA replication. Therefore, intensive studies have been carried out in the last two decades. Based on the sequence-derived features, various in silico approaches have been developed to identify microbial replication origins. In comparison with the in silico analysis, the experimental methods are time-consuming and labor-intensive, but convincing and reliable. A number of experimental methods have been used to identify and characterize microbial replication origins in vivo or in vitro. In addition, the availability of increasing complete microbial genomes and emerging approaches has created challenges and opportunities for identification and characterization of microbial replication origins in silico, as well as in vivo and in vitro.
This Research Topic is devoted to provide a comprehensive overview of DNA replication origins in microbial genomes, and we welcome the submissions of original research articles, reviews, min-reviews, methods article, perspective, and opinions that make a substantial and updated contribution to this field.
Take a look at the previous editions of this Research Topic here:
DNA Replication Origins in Microbial Genomes
DNA Replication Origins in Microbial Genomes, Volume II
Keywords: archaea, bacteria, yeast, replication origin, DNA replication, replication regulation, orisome, regulatory proteins, replication, DNA, protein, proteins, regulatory, regulation, cell, proliferation, inheritance, genetic, integrity, genome, genomes
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