Research Topic

The Role of Microglia in Synaptic Development and its Alterations in Neurodevelopmental Disorders

  • Submission closed.

About this Research Topic

Recent advances in the understanding of microglia functions suggest an emerging role for these cells in the normal development of the central nervous system (CNS) in addition to their traditional role as the immune cells of the brain. Indeed, a main function of microglia is to regulate programmed cell death-- ...

Recent advances in the understanding of microglia functions suggest an emerging role for these cells in the normal development of the central nervous system (CNS) in addition to their traditional role as the immune cells of the brain. Indeed, a main function of microglia is to regulate programmed cell death-- both as a traditional immune function and increasingly recognized as a critical mechanism for the developing human brain to prune synapses based on activity-dependent usage. These findings have resulted in a new model of the synapse as 'tripartate,' recognizing the important role of not just neurons and astrocytes but also microglia in the normal physiological function of the brain. Consequently, a major emerging area of inquiry is attempting to determine to what extent abnormalities in microglial function may contribute to neurodevelopmental disorders such as autism.

This Research Topic will explore the emerging dual role of microglia in both normal neurodevelopment and their potential to contribute to neurodevelopmental disease.


Keywords: microglia, brain development, neurodevelopmental disorders, microglial phagocytosis, synaptic pruning


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Recent Articles

Loading..

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..

Comments

Loading..

Add a comment

Add comment
Back to top