About this Research Topic
Peritoneal dialysis (PD) has been widely used in renal replacement therapy (RRT) for end-stage kidney disease (ESKD) and acute kidney injury (AKI) because of its convenience, home implementation, no need for large equipment, and its alignment with human physiology. Around 11% of patients with kidney failure worldwide are treated with PD.
Although some progress has been made in the research of PD devices, technology and peritoneal dialysate biocompatibility in recent years, there are several limitations. Of major concern is the infectious complications. Another limitation is the ion transport ability of PD. On the one hand, the ability to remove the uremic toxin and water is far below physiological renal function. On the other hand, PD fails to compensate for the intake of phosphate and sodium, resulting in high blood pressure. Therefore, further studies are needed on peritoneal physiology, pathophysiology, clinical prognosis, and complications in PD. This Research Topic welcomes original articles as well as key review articles that address the latest basic and clinical evidence on peritoneal dialysis. We also welcome those studies dealing with the normal condition of the renal function that will facilitate our understanding of PD.
Given these main objectives, this Research Topic includes, but is by no means limited to the following subtopics:
• Peritoneal membrane physiology and pathophysiology;
• Physiology and pathophysiology of solute clearance and ultrafiltration in peritoneal dialysis;
• Pathophysiology and molecular mechanisms of peritoneal inflammation and fibrosis in peritoneal dialysis;
• Physiology and pathophysiology of peritoneal ion and water transport;
• Pathophysiology and molecular mechanisms of cardiovascular complications in peritoneal dialysis;
• CKD-MBD in Peritoneal Dialysis;
• Clinical and basic study of new peritoneal dialysate;
• Basic research of Peritoneal Dialysis;
• Peritoneal membrane physiology in Automated Peritoneal Dialysis (APD).
Although some progress has been made in the research of PD devices, technology and peritoneal dialysate biocompatibility in recent years, there are several limitations. Of major concern is the infectious complications. Another limitation is the ion transport ability of PD. On the one hand, the ability to remove the uremic toxin and water is far below physiological renal function. On the other hand, PD fails to compensate for the intake of phosphate and sodium, resulting in high blood pressure. Therefore, further studies are needed on peritoneal physiology, pathophysiology, clinical prognosis, and complications in PD. This Research Topic welcomes original articles as well as key review articles that address the latest basic and clinical evidence on peritoneal dialysis. We also welcome those studies dealing with the normal condition of the renal function that will facilitate our understanding of PD.
Given these main objectives, this Research Topic includes, but is by no means limited to the following subtopics:
• Peritoneal membrane physiology and pathophysiology;
• Physiology and pathophysiology of solute clearance and ultrafiltration in peritoneal dialysis;
• Pathophysiology and molecular mechanisms of peritoneal inflammation and fibrosis in peritoneal dialysis;
• Physiology and pathophysiology of peritoneal ion and water transport;
• Pathophysiology and molecular mechanisms of cardiovascular complications in peritoneal dialysis;
• CKD-MBD in Peritoneal Dialysis;
• Clinical and basic study of new peritoneal dialysate;
• Basic research of Peritoneal Dialysis;
• Peritoneal membrane physiology in Automated Peritoneal Dialysis (APD).
Keywords: end-stage kidney disease (ESKD), acute kidney injury (AKI), peritoneal membrane, dialysis
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
