About this Research Topic
Clinical tissue specimens represent the gold standard resource from which biomedical research is based upon. Historically, they have been optimized for morphologic evaluative purposes through formalin fixation followed by paraffin wax embedding (FFPE), a process which creates a static product not conducive for functional studies. This has necessitated the use of surrogate models for basic research, an approach that has limited appeal. This has also resulted in a number of promising and rapidly developing technologies from disparate -omic based technologies to never reach the level of clinical application due to this barrier. Innovative approaches to the processing of tissue specimens needs to be investigated in order to take full advantage of what technology can reveal behind the cellular image.
The goal of this Research topic is to bring together collections of papers that individually or collectively show the potential of how emerging technologies can improve upon cancer diagnostics, and how innovations in pathology laboratory processing methods can be integrated into everyday workflows to accommodate these technologies.
Scope and information for Authors
We welcome the submission of manuscripts including, but not limited to, the following topics:
• Assays developed to detect analytes (exosomes, metabolites, proteins, or other types of molecules) secreted by or extractable from tumor cells and collectable or detectable in tissue free sources (body-fluids, tissue specimen washes, etc.).
• Innovation in tissue processing that can extract analytes from tissues and cells without destroying the integrity of the source. Cytologic and morphologic preservation should be emphasized.
• Innovations in tissue processing that can lead to organoid development or other functional medicine based research, without detracting from the originating clinical specimen.
The goal of this Research topic is to bring together collections of papers that individually or collectively show the potential of how emerging technologies can improve upon cancer diagnostics, and how innovations in pathology laboratory processing methods can be integrated into everyday workflows to accommodate these technologies.
Scope and information for Authors
We welcome the submission of manuscripts including, but not limited to, the following topics:
• Assays developed to detect analytes (exosomes, metabolites, proteins, or other types of molecules) secreted by or extractable from tumor cells and collectable or detectable in tissue free sources (body-fluids, tissue specimen washes, etc.).
• Innovation in tissue processing that can extract analytes from tissues and cells without destroying the integrity of the source. Cytologic and morphologic preservation should be emphasized.
• Innovations in tissue processing that can lead to organoid development or other functional medicine based research, without detracting from the originating clinical specimen.
Keywords: Triaging of Tissue, Tumor diagnosis staging, personalized therapeutics.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
