About this Research Topic
Incorporation of two or more potent pharmacophores into a single hybrid molecule is a growing trend in the design of novel therapeutic agents. Novel hybrids can demonstrate biological activities higher than those of the precursors together with much lower toxicity and reduced side effects. Also, such hybrids or conjugates may act as an effective chelating agents in the synthesis of novel biologically active metal-based therapeutics, sensors or fluorescent probes.
Coumarins of both natural and synthetic origin are well known for their broad array of biological activities and often demonstrate interesting ground and excited state characteristics. Diverse substituents make coumarins effective chelators of a large number of transition metal ions and enable their potential practical application as novel sensors, fluorescent dyes, markers, or imaging agents. Moreover, a notable increase in biological activity is frequently observed in coumarins upon their complexation with various metal salts, making the coordination chemistry of coumarins particularly interesting in terms of development of novel metal-based therapeutic agents. These properties of coumarins might be enhanced upon modifications which lead to the formation of coumarin hybrids with other potent pharmacophores such as triazoles, thiadiazoles, oxadiazoles, or other heterocycles. This Research Topic is dedicated to an isolation, structural characterization, examination of photophysical properties and biological activities of novel hybrids incorporating a coumarin nucleus.
We welcome Original Research, Review, Mini Review and Perspective articles on themes including, but not limited to:
• Isolation of novel coumarin hybrids and conjugates
• Spectroscopic characterization of novel coumarin hybrids
• Novel coumarin-based ligands and their transition metal complexes
• Novel coumarin-based sensors sensitive to various metal ions
• Novel coumarin-derived fluorescent dyes or fluorescence imaging agents
• Biological activities of novel coumarin derivatives
• Theoretical studies such as quantum-mechanical calculations (DFT) or molecular dynamics of novel biologically active coumarin hybrids
Contributions should consist of research carried out with use of various spectroscopic techniques, including electronic absorption, fluorescence emission (both steady state and time resolved), fluorescence lifetimes, FT-IR and Raman spectroscopy, NMR and NMR imaging spectroscopy, Confocal, Fluorescence Microscopy, Thermal studies, Chromatographic methods, XRD crystallography, and other instrumental techniques.
Coumarins of both natural and synthetic origin are well known for their broad array of biological activities and often demonstrate interesting ground and excited state characteristics. Diverse substituents make coumarins effective chelators of a large number of transition metal ions and enable their potential practical application as novel sensors, fluorescent dyes, markers, or imaging agents. Moreover, a notable increase in biological activity is frequently observed in coumarins upon their complexation with various metal salts, making the coordination chemistry of coumarins particularly interesting in terms of development of novel metal-based therapeutic agents. These properties of coumarins might be enhanced upon modifications which lead to the formation of coumarin hybrids with other potent pharmacophores such as triazoles, thiadiazoles, oxadiazoles, or other heterocycles. This Research Topic is dedicated to an isolation, structural characterization, examination of photophysical properties and biological activities of novel hybrids incorporating a coumarin nucleus.
We welcome Original Research, Review, Mini Review and Perspective articles on themes including, but not limited to:
• Isolation of novel coumarin hybrids and conjugates
• Spectroscopic characterization of novel coumarin hybrids
• Novel coumarin-based ligands and their transition metal complexes
• Novel coumarin-based sensors sensitive to various metal ions
• Novel coumarin-derived fluorescent dyes or fluorescence imaging agents
• Biological activities of novel coumarin derivatives
• Theoretical studies such as quantum-mechanical calculations (DFT) or molecular dynamics of novel biologically active coumarin hybrids
Contributions should consist of research carried out with use of various spectroscopic techniques, including electronic absorption, fluorescence emission (both steady state and time resolved), fluorescence lifetimes, FT-IR and Raman spectroscopy, NMR and NMR imaging spectroscopy, Confocal, Fluorescence Microscopy, Thermal studies, Chromatographic methods, XRD crystallography, and other instrumental techniques.
Keywords: Coumarins, Hybrids, Ligands, Transition metal complexes, Biological activity, Sensors
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
