Diabetes mellitus (DM) is one of the most serious diseases that endanger human health. According to the International Diabetes Federation, the number of people with DM is expected to reach 700 million by 2045. About 90% of patients with DM have type 2 diabetes mellitus (T2DM), and the prevalence is higher in middle- and high-income countries than in low-income countries. Diabetic kidney disease (DKD) is a kind of chronic kidney disease caused by DM, which is the leading cause of the end-stage renal disease (ESRD). About 30%-50% of ESRD in the world is caused by DKD. Current research results indicate that metabolic disorders, hemodynamic changes, inflammatory response, cytokines, oxidative stress, genetic factors, kinin system and autophagy are all involved in the pathogenesis of DKD. But the mechanism of DKD is so complex that it has not been clarified clearly.
This Research Topic aims at providing a forum for researchers to communicate research related to the frontiers of DKD. We wish to deepen the recognition of DKD, develop novel management for the patients and improve their prognosis.
This topic will focus on the pathogenesis and clinical treatment of DKD. Original basic and clinical research on the following subtopics is encouraged:
• The role played by glomerular podocytes or thylakoid cells in DKD
• The involvement of immune cells and tubular epithelial cells in the mechanisms of inflammation, interstitial fibrosis or glomerulosclerosis in DKD
• The differential diagnosis of DKD and non-DKD, and the study of diagnostic models
• The novel clinical and pathological indicators related to the prognosis in DKD
• The frontiers of drug therapy in DKD
Diabetes mellitus (DM) is one of the most serious diseases that endanger human health. According to the International Diabetes Federation, the number of people with DM is expected to reach 700 million by 2045. About 90% of patients with DM have type 2 diabetes mellitus (T2DM), and the prevalence is higher in middle- and high-income countries than in low-income countries. Diabetic kidney disease (DKD) is a kind of chronic kidney disease caused by DM, which is the leading cause of the end-stage renal disease (ESRD). About 30%-50% of ESRD in the world is caused by DKD. Current research results indicate that metabolic disorders, hemodynamic changes, inflammatory response, cytokines, oxidative stress, genetic factors, kinin system and autophagy are all involved in the pathogenesis of DKD. But the mechanism of DKD is so complex that it has not been clarified clearly.
This Research Topic aims at providing a forum for researchers to communicate research related to the frontiers of DKD. We wish to deepen the recognition of DKD, develop novel management for the patients and improve their prognosis.
This topic will focus on the pathogenesis and clinical treatment of DKD. Original basic and clinical research on the following subtopics is encouraged:
• The role played by glomerular podocytes or thylakoid cells in DKD
• The involvement of immune cells and tubular epithelial cells in the mechanisms of inflammation, interstitial fibrosis or glomerulosclerosis in DKD
• The differential diagnosis of DKD and non-DKD, and the study of diagnostic models
• The novel clinical and pathological indicators related to the prognosis in DKD
• The frontiers of drug therapy in DKD