About this Research Topic
RNA binding proteins (RBPs) regulate the life of RNA, from transcription to translation. RBPs include splicing factors, translational factors and proteins involved in RNA export, stabilization, degradation and modification. By prediction analysis of gene function, many proteins are identified as RBPs, and their roles in cells and organs are gradually understood by basic molecular research. However, some RBPs are not fully understood yet. Recently, several RBPs have been identified as candidate proteins for neurological diseases, such as neurodegenerative, neurodevelopmental and psychiatric diseases based on genetic analysis of clinical specimen using next-generation sequencing technology. To understand such diseases, it is important to elucidate the functions and roles of RBPs in the central nervous system.
In this Research Topic, we aim to collect articles about RBPs which aim to understand their roles in organisms at a deeper level. There are numerous genes that have been allocated to the GO term 'RNA binding' in GO. For some of them, the cellular function has not been fully elucidated and is required to be explored by researchers, whereas exome sequencing has already revealed their relation to neurological diseases. For instance, RBPs such as splicing factors, DDXs, HNRNPs, eIF proteins, and RBPs complex like THOC have been revealed as candidate genes in neurodevelopmental and psychiatric diseases. Therefore, the next step is to clarify their function and connect them to the symptoms of such diseases.
The scope of this Research Topic encompasses research (biochemical, cell biological, physiological and genetic study) about RBPs and the systematic review of the correlation of their function to neurological diseases. Therefore, we welcome manuscripts addressing, but not limited to, the following themes:
• The function of splicing factors and the genes regulated by them in the central nervous system.
• The role of specific RBP in RNA processing, transport, translation and degradation.
• The relation of RBPs to symptoms of neurological diseases.
• Study on specific RNA target of RBPs.
• Translational machinery focusing on RBPs.
• Additional/novel functions of known RBPs.
In this Research Topic, we aim to collect articles about RBPs which aim to understand their roles in organisms at a deeper level. There are numerous genes that have been allocated to the GO term 'RNA binding' in GO. For some of them, the cellular function has not been fully elucidated and is required to be explored by researchers, whereas exome sequencing has already revealed their relation to neurological diseases. For instance, RBPs such as splicing factors, DDXs, HNRNPs, eIF proteins, and RBPs complex like THOC have been revealed as candidate genes in neurodevelopmental and psychiatric diseases. Therefore, the next step is to clarify their function and connect them to the symptoms of such diseases.
The scope of this Research Topic encompasses research (biochemical, cell biological, physiological and genetic study) about RBPs and the systematic review of the correlation of their function to neurological diseases. Therefore, we welcome manuscripts addressing, but not limited to, the following themes:
• The function of splicing factors and the genes regulated by them in the central nervous system.
• The role of specific RBP in RNA processing, transport, translation and degradation.
• The relation of RBPs to symptoms of neurological diseases.
• Study on specific RNA target of RBPs.
• Translational machinery focusing on RBPs.
• Additional/novel functions of known RBPs.
Keywords: RNA binding proteins, splicing factor, neurological diseases, neurodevelopmental diseases, psychiatric diseases
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
