Axonopathy in Neurodegenerative Disease

197.3K

views

72

authors

16

articles

Editorial

23 October 2018

Editorial: Axonopathy in Neurodegenerative Disease

Robert W. Burgess

and

Samuel D. Crish

11,326 views

8 citations

Editors

6

Samuel David Crish

Northeast Ohio Medical University

North Texas Eye Research Institute, University of North Texas Health Science Center

Christine M Dengler-Crish

Northeast Ohio Medical University

Brett R Schofield

Northeast Ohio Medical University

Jason R Richardson

Florida International University

Robert W. Burgess

Jackson Laboratory

Impact

About

Axons are the major output processes of neurons. Normal axonal function is due to a complex relationship between a constellation of signaling molecules, molecular motors, mitochondria, structural elements, and ion channels of axons and glia. Recently, axonopathy, broadly defined as functional or structural defects in the axon or its terminal, has been established as a major early contributor to the genesis, progression, and symptomology of neurodegenerative disorders. These changes are common across a wide range of neurodegenerations including amyotrophic lateral sclerosis, Huntington’s, Parkinson’s, and Alzheimer’s diseases, glaucoma, and as a result of neurotoxin exposure. Despite the varied locations and progression of these conditions, axonal pathologies share many features.

The aim of this research topic is to assemble a series of original research papers, reviews, and commentaries that will illustrate both the commonalities and important differences across these diseases so that we may better understand and investigate this important topic.

Axons are the major output processes of neurons. Normal axonal function is due to a complex relationship between a constellation of signaling molecules, molecular motors, mitochondria, structural elements, and ion channels of axons and glia. Recently, axonopathy, broadly defined as functional or structural defects in the axon or its terminal, has been established as a major early contributor to the genesis, progression, and symptomology of neurodegenerative disorders. These changes are common across a wide range of neurodegenerations including amyotrophic lateral sclerosis, Huntington’s, Parkinson’s, and Alzheimer’s diseases, glaucoma, and as a result of neurotoxin exposure. Despite the varied locations and progression of these conditions, axonal pathologies share many features.

The aim of this research topic is to assemble a series of original research papers, reviews, and commentaries that will illustrate both the commonalities and important differences across these diseases so that we may better understand and investigate this important topic.

Download ebook

Share

Editors

Samuel David Crish

Northeast Ohio Medical University

North Texas Eye Research Institute, University of North Texas Health Science Center

Christine M Dengler-Crish

Northeast Ohio Medical University

Brett R Schofield

Northeast Ohio Medical University

Jason R Richardson

Florida International University

Robert W. Burgess

Jackson Laboratory

Impact

197,272 Total views

150,473 Article views

33,364 Article downloads

13,435 Topic views

Published In

Journal Thumbnail

Frontiers in Neuroscience

Neurodegeneration

Journal Thumbnail

Frontiers in Psychiatry

Neurodegeneration

Journal Thumbnail

Frontiers in Neurology

Neurodegeneration

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Suggest a topic