About this Research Topic
Genetic factors greatly contribute to deciding transfusion and transplantation outcomes. Ranging from acute hemolytic complications, allograft rejections, chronic immunosuppression, and mortality multiple clinical adversities have been reported to date. Genetic variations occurring in the HLA and blood group-associated genes have been identified as the major factor leading to inter-individual variability and have been extensively studied in the past decade. With the availability of high throughput sequencing techniques complemented by the advent of next-generation sequencing strategies, allele-level genotyping is emerging as an accurate high-resolution method for clinically matching HLA and RBC antigens between the donor and the recipient
Recent insights into the population or ethnicity-specific prevalence of HLA and RBC alleles demand the systematic organization and maintenance of regional datasets and repositories. Such efforts can be largely motivated by the availability of population-scale genomic datasets in combination with the utilization of advanced bioinformatics tools. Besides, there still exists a paucity of studies exploring the landscape of these alleles in numerous populations that are under-represented on a global scale. These collected findings would greatly contribute to understanding the diverse genetic epidemiology, population-specific disease susceptibilities, and blood requirements.
This Research Topic edition aims to shed light on the recent advancements in transplantation and transfusion genomics. We are glad to encourage submissions of original articles, reviews, short communications, and case studies focussing on, but not limited to, the following topics:
• Genetic epidemiology of HLA/HNA/RBC alleles in various global populations
• Novel methods in genomic analysis of HLA/HNA/RBC alleles
• Discoveries on novel disease associations of HLA/HNA/RBC alleles
Recent insights into the population or ethnicity-specific prevalence of HLA and RBC alleles demand the systematic organization and maintenance of regional datasets and repositories. Such efforts can be largely motivated by the availability of population-scale genomic datasets in combination with the utilization of advanced bioinformatics tools. Besides, there still exists a paucity of studies exploring the landscape of these alleles in numerous populations that are under-represented on a global scale. These collected findings would greatly contribute to understanding the diverse genetic epidemiology, population-specific disease susceptibilities, and blood requirements.
This Research Topic edition aims to shed light on the recent advancements in transplantation and transfusion genomics. We are glad to encourage submissions of original articles, reviews, short communications, and case studies focussing on, but not limited to, the following topics:
• Genetic epidemiology of HLA/HNA/RBC alleles in various global populations
• Novel methods in genomic analysis of HLA/HNA/RBC alleles
• Discoveries on novel disease associations of HLA/HNA/RBC alleles
Keywords: Transplantation, Transfusion, Human Leukocyte Antigens (HLA), RBC antigens, Human Neutrophil Antigens (HNA), Genomics, Data analysis, Recent advances, Future perspectives
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