Effects of Glucose and Lipid Metabolism on Vascular Endothelial Dysfunction

With the continuous improvement of people's quality of life in the world, the incidence rate of diabetes has increased year by year. Abnormality of glucose level and lipid metabolism has led to a number of serious problems that play a crucial role in the development of various types of diabetes mellitus. It also induces a series of serious complications, such as atherosclerosis, cardiovascular events and microvascular disease. Glucose and lipid metabolism, causing endothelial dysfunction, are two major risk factors involved in the pathogeneses of these diseases. Among these, type 2 diabetes and gestational diabetes are two common types of diabetes that are easily complicated with vascular disease, and we should pay special attention to both. At present, many studies have shown that glucose and lipid metabolism in diabetes participates in vascular dysfunction. However, the mechanism is still unclear and more studies are needed to explore it.

This Research Topic aims to summarize the mechanism of glucose and lipid metabolism underlying vascular dysfunction in various types of diabetes. It will discuss how changes in glucose and lipid metabolism affect the function of vascular endothelial cells in diabetes. It also seeks to provide a new perspective on the sub-mechanism of glucose and lipid metabolism and vascular dysfunction.

Potential sub-topics include but are not limited to:
• Effect of blood glucose fluctuation or adipose tissue hormone on vascular endothelial function in type 2 diabetes
• Effect of glucose or lipid metabolism on placental vascular endothelial function in gestational diabetes
• Effect of glucose metabolism on vascular endothelial function in premature ovarian failure
• Effect of hypoglycemic drugs on vascular endothelial dysfunction in type 2 diabetes