Research Topic

Role of Oxidative Stress in Oral Diseases

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There is overwhelming evidence that chronic periodontitis (also called periodontitis), a chronic inflammatory disease characterized by gingival bleeding, connective tissue destruction and alveolar bone resorption leading to tooth loss, has also been associated with a state of chronic inflammation both linked ...

There is overwhelming evidence that chronic periodontitis (also called periodontitis), a chronic inflammatory disease characterized by gingival bleeding, connective tissue destruction and alveolar bone resorption leading to tooth loss, has also been associated with a state of chronic inflammation both linked to a systemic oxidative stress (OS) state and reduced global anti-oxidant capacity. The production of reactive oxygen species (ROS), including superoxide, hydrogen peroxide and hydroxyl anions, an essential protective mechanism against diseases, is associated with phagocytic infiltration as the host defense against bacterial pathogens. On the other hand, increased production of ROS leads to of DNA, lipids and proteins oxidisation and finally to tissue damage. Clinical studies revealed that periodontitis induces excessive ROS production in periodontal tissue, gingival crevicular fluid and saliva while experimental animal models confirmed that periodontitis induced increased hydrogen peroxide in polymorphonuclear leukocytes, higher levels of lipid peroxidation and hydrogen peroxides. Furthermore, with the progression of periodontitis, ROS produced by periodontal inflammation diffused into the blood stream which may gradually injure multiple organs and negatively affect systemic health. Therefore, a Research Topic in the Frontiers in Physiology regarding the role of oxidative stress in periodontal disease will be a subject of high scientific interest.
Apart of periodontal disease, reactive oxygen species are also involved in the pathogenesis of head and neck carcinogenesis and other oral conditions (e.g. dental caries), being striking targets for therapeutical interventions.

In this context, this Research Topic is aimed to offer a snapshot of the present knowledge and questions raised in this field. Submission of original research reports, review articles, commentaries, perspectives or short communications in the following topics (but not limited to) is encouraged regarding:

• The importance of the oxidative stress in the periodontal disease and oral cancer, dental caries, endodontics, implant pathology and other oral conditions;
• The source or sources of super-oxide production (e.g. inflammation, nutrition) in periodontal disease, pre-cancer and oral cancer;
• The relationship between oxidative stress markers, periodontal disease, and systemic health (e.g. diabetes mellitus, metabolic syndrome, pregnancy, atherosclerosis, peripheral vascular disease, rheumatoid arthritis, chronic renal failure, obstructive sleep apnea syndrome, HIV etc.);

• Increased oxidative stress is a risk factor for progression of periodontitis or carcinogenesis;
• Oxidative stress levels in experimental periodontitis models;
• The influence of tobacco smoking on selected factors of oxidative stress in patients with periodontitis or with oral cancer;
• Effects of various therapies on blood oxidative stress in patients with periodontal disease or oral cancer;
• Effects of therapies targeting OS (e.g. protein transduction treatments, bone targeted antiresorptives(bis-enoxacin and alendronate) or antioxidants) on chronic periodontitis or oral cancer.


Keywords: Periodontitis, Periodontal disease, Reactive oxygen species, Oxidative stress, oral cancer, saliva, blood


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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