About this Research Topic
Intervertebral Disc degeneration (IVDD) is one of the most common age-related bone degenerative diseases and causes a huge economic burden worldwide. The intervertebral disc consists of the nucleus pulposus and the annulus fibrosus. The nucleus pulposus is an elastic jelly material which is located between the cartilage plate and the annulus fibrosus and is composed of crisscross fibrous reticular structures and proteoglycan mucoid matrix. They are of great significance in dispersing pressure and supporting bending with large angles and high frequencies. The degeneration of the nucleus pulposus cells is the main cause of IVDD.
Cellular senescence with multiple factors involved is currently one of the fastest-growing branches of science, including ROS accumulation, telomere shortening, DNA damage, gene senescence and biomacromolecule cross-link. Senescent cells will experience a decline in function and metabolism, finally leading to organism degeneration.
This Research Topic aims to study the senescence of the nucleus pulposus in its degeneration and IVDD and to explore the molecular mechanisms of nucleus pulposus senescence. Thereby delaying the senescence and degeneration of the nucleus pulposus.
This Research Topic welcomes articles about, but not limited to the followings:
● Novel molecular mechanisms of nucleus pulposus senescence
● Novel indicators of nucleus pulposus senescence for early diagnosis
● Novel targets of nucleus pulposus senescence for precision treatment
Cellular senescence with multiple factors involved is currently one of the fastest-growing branches of science, including ROS accumulation, telomere shortening, DNA damage, gene senescence and biomacromolecule cross-link. Senescent cells will experience a decline in function and metabolism, finally leading to organism degeneration.
This Research Topic aims to study the senescence of the nucleus pulposus in its degeneration and IVDD and to explore the molecular mechanisms of nucleus pulposus senescence. Thereby delaying the senescence and degeneration of the nucleus pulposus.
This Research Topic welcomes articles about, but not limited to the followings:
● Novel molecular mechanisms of nucleus pulposus senescence
● Novel indicators of nucleus pulposus senescence for early diagnosis
● Novel targets of nucleus pulposus senescence for precision treatment
Keywords: Nucleus pulposus, senescence, intervertebral disc, degeneration, molecular mechanism
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
