About this Research Topic
The goal of this Research Topic is to bring together research papers and reviews of current state of the art literature on more objective methods for assessment of donor organ quality. It is vital for donor clinical demographic data to be complemented by molecular and/or histopathological assessment of tissue injury and viability. Organ assessment can also be performed during organ preservation by dynamically preserving organs with ex-vivo machine perfusion (hypo- or normothermic) and we also welcome papers focusing on organ assessment during ex-vivo machine preservation.
These studies can include any organ and refer to experimental/clinical transplantation of kidney, liver, pancreas, lung and heart. The submissions can include experimental animal studies, clinical studies, studies using clinical human samples and narrative reviews covering, but not limited to, the following sub-topics.
- Pathophysiology of tissue injury during deceased organ donation
- -omics profiling of donor organs (transcriptomics, proteomics)
- Biomarkers of donor organ quality predictive of outcomes
- Novel methods of histopathological evaluation of donor organs
- Molecular and functional evaluation of organ quality by ex-vivo machine perfusion
Keywords: Organ viability, Biomarkers, Injury, Proteomics, Transcriptomics, Histopathological scores, Molecular mechanisms, Donor profiling
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.