Cardiorenal Signaling in Kidney Health and Disease

The crosstalk between the cardiovascular and renal systems is a fundamental part of human physiology. The dysregulated communication between these two systems eventually leads to a series of pathologies, falling under the umbrella term of Cardiorenal Syndrome, where the failure of either one of these system leads to the failure of both. Understanding the signaling mechanisms that underlie the cardiorenal crosstalk with each other is therefore fundamental to ultimately develop effective therapeutic strategies these pathologies.

Cardiorenal syndrome (CRS) is a multifactorial entity that results in dysfunction in both systems that are interconnected with each other. The pathophysiological mechanisms involved are multiple and include, among others, hemodynamic stress, the neurohormonal axis, chronic inflammatory states, and oxidative stress. The exhaustive study of these mechanisms from the experimental models to the clinical findings in patients with this syndrome will allow the search for new therapeutic targets in the future.

This Research Topic welcomes basic, translational, clinical, and applied research that improves our understanding of the cardiorenal interaction mechanism in renal physiology and pathophysiology. Potential areas of interest may include, but are not limited to:
- inflammation
- oxidative stress.
- heart-kidney interactions.
- cardiac-kidney interactions in special populations such as patients with diabetes mellitus and kidney transplant.
- hemodynamic interactions of the heart and kidney, in health and disease.
- neurohormonal activation, cytokines, and biochemical perturbations.
- (intra)renal renin angiotensin aldosterone system, renal dopaminergic system, action of natriuretic peptides.
- development of novel biomarkers to detect early injury, to aid prognosis, and introduction of novel imaging techniques.
- mechanism of disease, diagnostics, therapies, palliative care.

We welcome the submission of different article types to this collection, especially reviews, mini-reviews, and original research papers. For a complete list of article types that can be considered in this Research Topic, please follow this link.

Even though abstract submission is not mandatory, we encourage all interested researchers to submit an abstract before submitting their manuscript. Abstracts do not have to coincide with the final abstract of the manuscripts.

Topic Editor Silvana Della Penna is affiliated to Ttopstart Life Science, Netherlands. All other Topic Editors declare no competing interests with regards to the Research Topic subject.