About this Research Topic
Immune aging and immunosenescence are associated with the loss of critical immune functions and render the host susceptible to inflammation. Senescent immune systems lose their capacity to maximize inflammatory protection, which can result in aging-related diseases as well as tissue-damaging conditions. Immune cell longevity is tightly related to the functional integrity of telomeres which are the key biomarkers of aging. Telomerase insufficiency is linked to premature immunological aging in those with autoimmune disorders such as rheumatoid arthritis and Graves disease. Additionally, patients with autoimmune diseases experience other defects in DNA repair. Understanding of telomere dynamics and structural integrity is developing, and diverse patterns in various autoimmune illnesses reveal a wide range of molecular processes defining the interface between long-term immunological activation and immune system aging. While there is evidence to support the connection between autoimmunity and aging-related disorders, further research is needed to understand the molecular underpinnings and actual clinical data.
The goal of this Research Topic is to provide a forum to advance research on the contribution of the relationships between autoimmunity and aging-related disorders as well as to explore innovative real-world epidemiological evidence and biological mechanistic insights in an attempt to achieve a dual beneficial impact on autoimmunity and aging.
We welcome the submission of manuscripts (Research Article, Brief Research Article, Mini-Review, and Review) focusing on, but not limited to, the following themes:
1) The incidence, prevalence, quality of life, and mortality of aging-related diseases in patients with autoimmune disorders
2) Shared genetic, lifestyle, and environmental factors of autoimmune diseases and aging-related disorders
3) Common serum and cerebrospinal fluid biomarkers in autoimmune diseases and aging-related disorders
4) Neuroimaging findings of autoimmune diseases in patients with aging-related disorders
5) Biological mechanisms for neurodegenerative diseases in patients with autoimmune diseases
6) Efficacy and safety of drugs for autoimmune disorders using real-world evidence in patients with aging-related disorders
7) Shared metabolomics between aging-related diseases and autoimmune disorders
8) Flowmetry profiling of autoimmune diseases in patients with aging-related disorders
The goal of this Research Topic is to provide a forum to advance research on the contribution of the relationships between autoimmunity and aging-related disorders as well as to explore innovative real-world epidemiological evidence and biological mechanistic insights in an attempt to achieve a dual beneficial impact on autoimmunity and aging.
We welcome the submission of manuscripts (Research Article, Brief Research Article, Mini-Review, and Review) focusing on, but not limited to, the following themes:
1) The incidence, prevalence, quality of life, and mortality of aging-related diseases in patients with autoimmune disorders
2) Shared genetic, lifestyle, and environmental factors of autoimmune diseases and aging-related disorders
3) Common serum and cerebrospinal fluid biomarkers in autoimmune diseases and aging-related disorders
4) Neuroimaging findings of autoimmune diseases in patients with aging-related disorders
5) Biological mechanisms for neurodegenerative diseases in patients with autoimmune diseases
6) Efficacy and safety of drugs for autoimmune disorders using real-world evidence in patients with aging-related disorders
7) Shared metabolomics between aging-related diseases and autoimmune disorders
8) Flowmetry profiling of autoimmune diseases in patients with aging-related disorders
Keywords: Autoimmunity, Aging-related disordrs, immunosenescence
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
